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6dxz

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Current revision (06:15, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6dxz' size='340' side='right'caption='[[6dxz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6dxz' size='340' side='right'caption='[[6dxz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DXZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DXZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=27L:4-(2,4,4-TRIMETHYLPENTAN-2-YL)PHENOL'>27L</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TON:2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL'>TON</scene>, <scene name='pdbligand=TRT:FRAGMENT+OF+TRITON+X-100'>TRT</scene>, <scene name='pdbligand=WTF:[2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone'>WTF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=27L:4-(2,4,4-TRIMETHYLPENTAN-2-YL)PHENOL'>27L</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TON:2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL'>TON</scene>, <scene name='pdbligand=TRT:FRAGMENT+OF+TRITON+X-100'>TRT</scene>, <scene name='pdbligand=WTF:[2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone'>WTF</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-(long-chain-acyl)ethanolamine_deacylase N-(long-chain-acyl)ethanolamine deacylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.60 3.5.1.60] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dxz OCA], [https://pdbe.org/6dxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dxz RCSB], [https://www.ebi.ac.uk/pdbsum/6dxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dxz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dxz OCA], [http://pdbe.org/6dxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dxz RCSB], [http://www.ebi.ac.uk/pdbsum/6dxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dxz ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NAAA_RABIT NAAA_RABIT] Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine.[UniProtKB:Q5KTC7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: European rabbit]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gebai, A]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Gorelik, A]]
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[[Category: Gebai A]]
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[[Category: Illes, K]]
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[[Category: Gorelik A]]
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[[Category: Nagar, B]]
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[[Category: Illes K]]
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[[Category: Piomelli, D]]
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[[Category: Nagar B]]
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[[Category: Endocannabinoid]]
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[[Category: Piomelli D]]
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[[Category: Hydrolase]]
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[[Category: Lipase]]
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Current revision

Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent benzothiazole-piperazine inhibitor ARN19702, in presence of Triton X-100

PDB ID 6dxz

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OCA

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