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6e7d

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Current revision (06:20, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6e7d' size='340' side='right'caption='[[6e7d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6e7d' size='340' side='right'caption='[[6e7d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E7D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Clec2d, Clrb, Ocil ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Klrb1b, Klrb1d, Ly55d, Nkrp1b, Nkrp1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [http://pdbe.org/6e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [http://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [https://pdbe.org/6e7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [https://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE]] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref> [[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
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[https://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Balaji, G R]]
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[[Category: Balaji GR]]
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[[Category: Berry, R]]
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[[Category: Berry R]]
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[[Category: Rossjohn, J]]
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[[Category: Rossjohn J]]
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[[Category: C-type lectin related ligand]]
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[[Category: Immune complex]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Natural killer cell receptor]]
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Current revision

Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b

PDB ID 6e7d

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