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6mfb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 3-hydroxykynurenine transaminase from Aedes aegypti== | |
| + | <StructureSection load='6mfb' size='340' side='right'caption='[[6mfb]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6mfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MFB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfb OCA], [https://pdbe.org/6mfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mfb RCSB], [https://www.ebi.ac.uk/pdbsum/6mfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HKT_AEDAE HKT_AEDAE] Catalyzes the pyridoxal 5'-phosphate-dependent transamination of both 3-hydroxykynurenine and L-kynurenine to xanthurenic acid and kynurenic acid, respectively, preferentially using the alpha-ketoacid pyruvate, glyoxylate or oxaloacetate as the amino group acceptor (PubMed:11880382, PubMed:12220660). The affinity and catalytic efficiency for 3-hydroxykynurenine is higher than for L-kynurenine (PubMed:12220660). Involved in the detoxification of cytotoxic metabolite 3-hydroxykynurenine generated by the hydroxylation of L-kynurenine, an intermediate in the tryptophan catabolism pathway (PubMed:11880382, PubMed:12220660). Also catalyzes, although with a lesser efficiency, the transamination of alanine with glyoxylate as an amino group acceptor (PubMed:11880382). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the diet (Probable).<ref>PMID:11880382</ref> <ref>PMID:12220660</ref> <ref>PMID:11880382</ref> <ref>PMID:12220660</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Aedes aegypti]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Guido RVC]] |
| - | [[Category: | + | [[Category: Maciel LG]] |
| - | [[Category: | + | [[Category: Oliveira AA]] |
| + | [[Category: Romao TP]] | ||
| + | [[Category: Silva Filha MHNL]] | ||
| + | [[Category: Soares TA]] | ||
| + | [[Category: Dos Anjos JV]] | ||
Current revision
Crystal structure of 3-hydroxykynurenine transaminase from Aedes aegypti
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