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6mn2

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==Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA==
==Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA==
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<StructureSection load='6mn2' size='340' side='right' caption='[[6mn2]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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<StructureSection load='6mn2' size='340' side='right'caption='[[6mn2]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mn2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_bacterium Uncultured bacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SIS:(1S,2S,3R,4S,6R)-4,6-DIAMINO-3-{[(2S,3R)-3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL]OXY}-2-HYDROXYCYCLOHEXYL+3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-BETA-L-ARABINOPYRANOSIDE'>SIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.744&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5th0|5th0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SIS:(1S,2S,3R,4S,6R)-4,6-DIAMINO-3-{[(2S,3R)-3-AMINO-6-(AMINOMETHYL)-3,4-DIHYDRO-2H-PYRAN-2-YL]OXY}-2-HYDROXYCYCLOHEXYL+3-DEOXY-4-C-METHYL-3-(METHYLAMINO)-BETA-L-ARABINOPYRANOSIDE'>SIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(3')-acetyltransferase Aminoglycoside N(3')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.81 2.3.1.81] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mn2 OCA], [https://pdbe.org/6mn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mn2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mn2 OCA], [http://pdbe.org/6mn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mn2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mn2 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A059X981_9BACT A0A059X981_9BACT]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A]]
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[[Category: Uncultured bacterium]]
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[[Category: Michalska, K]]
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[[Category: Joachimiak A]]
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[[Category: Satchell, K J]]
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[[Category: Michalska K]]
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[[Category: Savchenko, A]]
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[[Category: Satchell KJ]]
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[[Category: Skarina, T]]
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[[Category: Savchenko A]]
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[[Category: Stogios, P J]]
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[[Category: Skarina T]]
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[[Category: Xu, Z]]
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[[Category: Stogios PJ]]
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[[Category: Yim, V]]
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[[Category: Xu Z]]
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[[Category: Acetyltransferase]]
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[[Category: Yim V]]
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[[Category: Aminoglycoside]]
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[[Category: Antibiotic resistance]]
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[[Category: Antibiotic_nat family]]
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[[Category: Coenzyme some]]
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[[Category: Csgid]]
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[[Category: Metagenome]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Sisomicin]]
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[[Category: Soil]]
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[[Category: Transferase]]
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[[Category: Transferase-antibiotic complex]]
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Current revision

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA

PDB ID 6mn2

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