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6moo

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Current revision (06:35, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6moo' size='340' side='right'caption='[[6moo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6moo' size='340' side='right'caption='[[6moo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6moo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MOO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6moo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MOO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A5F:N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diynyl]benzamide'>A5F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC_1, lpxC, C0044_32665, C8257_27020, CAZ10_21290, CGU42_01150, CW299_32585, DI492_11215, DN070_30465, DT376_11200, NCTC13719_04761, PAERUG_E15_London_28_01_14_00522, RW109_RW109_05745 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A5F:N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta+-1,3-diynyl]benzamide'>A5F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6moo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6moo OCA], [https://pdbe.org/6moo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6moo RCSB], [https://www.ebi.ac.uk/pdbsum/6moo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6moo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6moo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6moo OCA], [http://pdbe.org/6moo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6moo RCSB], [http://www.ebi.ac.uk/pdbsum/6moo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6moo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A072ZC86_PSEAI A0A072ZC86_PSEAI]] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.[HAMAP-Rule:MF_00388][SAAS:SAAS00531485]
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[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6moo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6moo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Andrews, L]]
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[[Category: Andrews L]]
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[[Category: Assar, Z]]
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[[Category: Assar Z]]
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[[Category: Cirz, R]]
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[[Category: Cirz R]]
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[[Category: Cohen, F]]
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[[Category: Cohen F]]
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[[Category: Holt, M C]]
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[[Category: Holt MC]]
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[[Category: Stein, A J]]
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[[Category: Stein AJ]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase lpxc pseudomonas aeruginosa]]
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[[Category: Hydrolase-inhibitor complex]]
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Current revision

Co-Crystal structure of P. aeruginosa LpxC-achn975 complex

PDB ID 6moo

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OCA

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