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6mql
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of GTPase Domain of Human Septin 12 Mutant T89M== | |
| - | + | <StructureSection load='6mql' size='340' side='right'caption='[[6mql]], [[Resolution|resolution]] 2.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MQL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mql OCA], [https://pdbe.org/6mql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mql RCSB], [https://www.ebi.ac.uk/pdbsum/6mql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mql ProSAT]</span></td></tr> |
| - | [[Category: Brandao-Neto | + | </table> |
| - | [[Category: Garratt | + | == Disease == |
| - | [[Category: Pereira | + | [https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: Ulian | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brandao-Neto J]] | ||
| + | [[Category: Castro DKSV]] | ||
| + | [[Category: Garratt RC]] | ||
| + | [[Category: Pereira HM]] | ||
| + | [[Category: Ulian APU]] | ||
Current revision
Crystal Structure of GTPase Domain of Human Septin 12 Mutant T89M
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