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6n9g

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==Crystal Structure of RGS7-Gbeta5 dimer==
==Crystal Structure of RGS7-Gbeta5 dimer==
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<StructureSection load='6n9g' size='340' side='right' caption='[[6n9g]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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<StructureSection load='6n9g' size='340' side='right'caption='[[6n9g]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n9g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N9G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n9g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N9G FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9g OCA], [http://pdbe.org/6n9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n9g RCSB], [http://www.ebi.ac.uk/pdbsum/6n9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9g ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.129&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n9g OCA], [https://pdbe.org/6n9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n9g RCSB], [https://www.ebi.ac.uk/pdbsum/6n9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n9g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RGS7_BOVIN RGS7_BOVIN]] Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.[UniProtKB:P49802] [[http://www.uniprot.org/uniprot/GNB5_MOUSE GNB5_MOUSE]] Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).[UniProtKB:A1L271][UniProtKB:O14775]
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[https://www.uniprot.org/uniprot/RGS7_BOVIN RGS7_BOVIN] Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.[UniProtKB:P49802]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6n9g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6n9g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Izard, T]]
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[[Category: Bos taurus]]
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[[Category: Martemyanov, K A]]
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[[Category: Large Structures]]
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[[Category: Patil, D N]]
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[[Category: Mus musculus]]
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[[Category: Rangarajan, E]]
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[[Category: Izard T]]
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[[Category: G protein signaling]]
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[[Category: Martemyanov KA]]
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[[Category: Rg]]
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[[Category: Patil DN]]
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[[Category: Signaling protein]]
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[[Category: Rangarajan E]]

Current revision

Crystal Structure of RGS7-Gbeta5 dimer

PDB ID 6n9g

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