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6nce

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Current revision (06:49, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6nce' size='340' side='right'caption='[[6nce]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6nce' size='340' side='right'caption='[[6nce]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nce]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NCE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nce]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NCE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.598&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOXN3, C14orf116, CHES1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nce OCA], [http://pdbe.org/6nce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nce RCSB], [http://www.ebi.ac.uk/pdbsum/6nce PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nce ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nce OCA], [https://pdbe.org/6nce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nce RCSB], [https://www.ebi.ac.uk/pdbsum/6nce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nce ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FOXN3_HUMAN FOXN3_HUMAN]] Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).<ref>PMID:16102918</ref>
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[https://www.uniprot.org/uniprot/FOXN3_HUMAN FOXN3_HUMAN] Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).<ref>PMID:16102918</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blacklow, S C]]
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[[Category: Synthetic construct]]
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[[Category: Bulyk, M L]]
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[[Category: Blacklow SC]]
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[[Category: Hallworth, A N]]
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[[Category: Bulyk ML]]
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[[Category: Jarrett, S M]]
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[[Category: Hallworth AN]]
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[[Category: Rogers, J M]]
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[[Category: Jarrett SM]]
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[[Category: Seegar, T C]]
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[[Category: Rogers JM]]
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[[Category: Waters, C T]]
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[[Category: Seegar TC]]
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[[Category: Dna binding protein]]
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[[Category: Waters CT]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna binding transcription factor activity]]
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[[Category: Forkhead]]
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[[Category: Regulation of transcription dna templated]]
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[[Category: Sequence specific dna binding]]
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Current revision

Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence

PDB ID 6nce

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