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6pnw

From Proteopedia

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Current revision (07:32, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6pnw' size='340' side='right'caption='[[6pnw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6pnw' size='340' side='right'caption='[[6pnw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pnw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PNW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pnw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PNW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ebx|3ebx]], [[6ebx|6ebx]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pnw OCA], [http://pdbe.org/6pnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pnw RCSB], [http://www.ebi.ac.uk/pdbsum/6pnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pnw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pnw OCA], [https://pdbe.org/6pnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pnw RCSB], [https://www.ebi.ac.uk/pdbsum/6pnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pnw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/3S1EC_LATSE 3S1EC_LATSE]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Binds to Torpedo marmorata nAChR (Kd=0.14 nM) (PubMed:7721859).<ref>PMID:7721859</ref>
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[https://www.uniprot.org/uniprot/3S1EC_LATSE 3S1EC_LATSE] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Binds to Torpedo marmorata nAChR (Kd=0.14 nM) (PubMed:7721859).<ref>PMID:7721859</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Erabutoxin-b, M(r) = 6861.1, a single 62 amino-acid chain folded by four disulfide bridges, was crystallized in a new orthorhombic form by using thiocyanate as crystallizing agent. The space group is P2(1)2(1)2(1) with a = 53.36 (4), b = 40.89 (4), c = 55.71 (5) A, V = 121533.1 A and Z = 8. X-ray diffraction data were recorded at the LURE synchrotron facility (lambda = 1.405 A). The structure was solved by molecular replacement and shows a dimeric association through an anti-parallel beta-sheet around the twofold non-crystallographic axis. The two independent molecules, one SCN- ion and 97 associated water molecules were refined by molecular dynamics and annealing techniques to R = 19.6% (10,913 Fobs, resolution 5-1.7 A). The thiocyanate ion is located at the interface of the dimer and close to the non-crystallographic twofold axis.
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Structure determination of a dimeric form of erabutoxin-b, crystallized from a thiocyanate solution.,Saludjian P, Prange T, Navaza J, Menez R, Guilloteau JP, Ries-Kautt M, Ducruix A Acta Crystallogr B. 1992 Aug 1;48 ( Pt 4):520-31. PMID:1418823<ref>PMID:1418823</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6pnw" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Laticauda semifasciata]]
[[Category: Laticauda semifasciata]]
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[[Category: Corfield, P W.R]]
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[[Category: Corfield PWR]]
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[[Category: Low, B W]]
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[[Category: Low BW]]
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[[Category: Neurotoxin]]
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[[Category: Snake venom]]
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[[Category: Toxin]]
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Current revision

X-RAY STRUCTURE OF ERABUTOXIN C, A DIMERIC NEUROTOXIN

PDB ID 6pnw

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