1nfi

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[[Image:1nfi.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nfi OCA], [http://www.ebi.ac.uk/pdbsum/1nfi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nfi RCSB]</span>
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'''I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX'''
'''I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Jacobs, M D.]]
[[Category: Jacobs, M D.]]
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[[Category: ankyrin repeat]]
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[[Category: Ankyrin repeat]]
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[[Category: complex (transcription regulation/ank repeat)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:28:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:29:40 2008''
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Revision as of 23:28, 2 May 2008

Image:1nfi.gif

Template:STRUCTURE 1nfi

I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX


Overview

The inhibitory protein, IkappaBalpha, sequesters the transcription factor, NF-kappaB, as an inactive complex in the cytoplasm. The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. It shows a stack of six IkappaBalpha ankyrin repeats facing the C-terminal domains of the NF-kappaB Rel homology regions. Contacts occur in discontinuous patches, suggesting a combinatorial quality for ankyrin repeat specificity. The first two repeats cover an alpha helically ordered segment containing the p65 nuclear localization signal. The position of the sixth ankyrin repeat shows that full-length IkappaBalpha will occlude the NF-kappaB DNA-binding cleft. The orientation of IkappaBalpha in the complex places its N- and C-terminal regions in appropriate locations for their known regulatory functions.

About this Structure

1NFI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an IkappaBalpha/NF-kappaB complex., Jacobs MD, Harrison SC, Cell. 1998 Dec 11;95(6):749-58. PMID:9865693 Page seeded by OCA on Sat May 3 02:28:20 2008

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