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6u33

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<StructureSection load='6u33' size='340' side='right'caption='[[6u33]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6u33' size='340' side='right'caption='[[6u33]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6u33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U33 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6u33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U33 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6u2s|6u2s]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lukNF, lukD, BTN44_02870, EP54_14125, EQ90_10595, ER624_13605, HMPREF3211_01500, NCTC10654_01892, NCTC13131_06007, RK64_09800 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u33 OCA], [https://pdbe.org/6u33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u33 RCSB], [https://www.ebi.ac.uk/pdbsum/6u33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u33 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u33 OCA], [http://pdbe.org/6u33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u33 RCSB], [http://www.ebi.ac.uk/pdbsum/6u33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u33 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LUKDV_STAA8 LUKDV_STAA8] Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin.<ref>PMID:12636257</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kozhaya, L]]
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[[Category: Staphylococcus aureus]]
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[[Category: Liu, J]]
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[[Category: Kozhaya L]]
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[[Category: Lu, M]]
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[[Category: Liu J]]
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[[Category: Torres, V J]]
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[[Category: Lu M]]
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[[Category: Unutmaz, D]]
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[[Category: Torres VJ]]
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[[Category: Alpha-toxin]]
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[[Category: Unutmaz D]]
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[[Category: Leukocidin]]
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[[Category: Mrsa]]
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[[Category: Pvl]]
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[[Category: Toxin]]
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Current revision

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus

PDB ID 6u33

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