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6upt

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6upt is ON HOLD
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==Tudor Domain of Tumor suppressor p53BP1 with MFP-2706==
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<StructureSection load='6upt' size='340' side='right'caption='[[6upt]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors: The, J., Dong, A., Headey, S., Gunzburg, M., Doak, B., James, L.I., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6upt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UPT FirstGlance]. <br>
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Description: Tudor Domain of Tumor suppressor p53BP1 with MFP-2706
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QFM:2-((2-chlorobenzyl)thio)-4,5-dihydro-1H-imidazole'>QFM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: James, L.I]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6upt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6upt OCA], [https://pdbe.org/6upt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6upt RCSB], [https://www.ebi.ac.uk/pdbsum/6upt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6upt ProSAT]</span></td></tr>
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[[Category: Dong, A]]
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</table>
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[[Category: Headey, S]]
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== Disease ==
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[[Category: The, J]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[[Category: Bountra, C]]
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== Function ==
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[[Category: Gunzburg, M]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[[Category: Arrowsmith, C.H]]
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== References ==
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[[Category: Brown, P.J]]
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<references/>
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[[Category: Edwards, A.M]]
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__TOC__
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[[Category: Structural Genomics Consortium (Sgc)]]
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</StructureSection>
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[[Category: Doak, B]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Doak B]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Gunzburg M]]
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[[Category: Headey S]]
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[[Category: James LI]]
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[[Category: The J]]

Current revision

Tudor Domain of Tumor suppressor p53BP1 with MFP-2706

PDB ID 6upt

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