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6v7n

From Proteopedia

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Current revision (08:05, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6v7n' size='340' side='right'caption='[[6v7n]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='6v7n' size='340' side='right'caption='[[6v7n]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V7N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V7N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v7n OCA], [https://pdbe.org/6v7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v7n RCSB], [https://www.ebi.ac.uk/pdbsum/6v7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v7n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v7n OCA], [http://pdbe.org/6v7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v7n RCSB], [http://www.ebi.ac.uk/pdbsum/6v7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v7n ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LICH_HUMAN LICH_HUMAN]] NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia;Cholesteryl ester storage disease;Wolman disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/LICH_HUMAN LICH_HUMAN] NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia;Cholesteryl ester storage disease;Wolman disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LICH_HUMAN LICH_HUMAN]] Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.<ref>PMID:15269241</ref> <ref>PMID:1718995</ref> <ref>PMID:7204383</ref> <ref>PMID:8112342</ref> <ref>PMID:9633819</ref>
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[https://www.uniprot.org/uniprot/LICH_HUMAN LICH_HUMAN] Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.<ref>PMID:15269241</ref> <ref>PMID:1718995</ref> <ref>PMID:7204383</ref> <ref>PMID:8112342</ref> <ref>PMID:9633819</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sterol esterase]]
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[[Category: Han S]]
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[[Category: Han, S]]
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[[Category: Cholesteryl ester storage disease]]
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[[Category: Hydrolase]]
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[[Category: Lysosomal acid lipase]]
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Current revision

Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)

PDB ID 6v7n

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