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6v9s

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Current revision (08:06, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6v9s' size='340' side='right'caption='[[6v9s]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6v9s' size='340' side='right'caption='[[6v9s]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V9S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V9S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JHC:[(2S)-2-[(2S)-butan-2-yl]-4-(5-chloro-1,3-benzoxazol-2-yl)-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone'>JHC</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JHC:[(2S)-2-[(2S)-butan-2-yl]-4-(5-chloro-1,3-benzoxazol-2-yl)-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone'>JHC</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9s OCA], [http://pdbe.org/6v9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v9s RCSB], [http://www.ebi.ac.uk/pdbsum/6v9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9s OCA], [https://pdbe.org/6v9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v9s RCSB], [https://www.ebi.ac.uk/pdbsum/6v9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
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[https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6v9s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6v9s" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Drabek, M]]
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[[Category: Pyrococcus abyssi GE5]]
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[[Category: Gmeiner, P]]
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[[Category: Drabek M]]
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[[Category: Hellmann, J]]
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[[Category: Gmeiner P]]
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[[Category: Huebner, H]]
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[[Category: Hellmann J]]
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[[Category: Kolb, P]]
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[[Category: Huebner H]]
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[[Category: Kraus, F]]
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[[Category: Kolb P]]
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[[Category: Proell, T]]
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[[Category: Kraus F]]
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[[Category: Rosenbaum, D M]]
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[[Category: Proell T]]
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[[Category: Weikert, D]]
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[[Category: Rosenbaum DM]]
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[[Category: Yin, J]]
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[[Category: Weikert D]]
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[[Category: Gpcr]]
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[[Category: Yin J]]
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[[Category: Orexin receptor]]
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[[Category: Selective ligand]]
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[[Category: Signaling protein]]
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Current revision

Structure-based development of subtype-selective orexin 1 receptor antagonists

PDB ID 6v9s

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