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6veb

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Current revision (08:10, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6veb' size='340' side='right'caption='[[6veb]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='6veb' size='340' side='right'caption='[[6veb]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6veb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VEB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6veb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica Salmonella enterica subsp. enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VEB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PQ2:3,3,3,3-[(7S,8S,12S,13S)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,12,18-tetrayl]tetrapropanoic+acid'>PQ2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6veb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6veb OCA], [http://pdbe.org/6veb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6veb RCSB], [http://www.ebi.ac.uk/pdbsum/6veb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6veb ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PQ2:3,3,3,3-[(7S,8S,12S,13S)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,1+2,18-tetrayl]tetrapropanoic+acid'>PQ2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6veb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6veb OCA], [https://pdbe.org/6veb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6veb RCSB], [https://www.ebi.ac.uk/pdbsum/6veb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6veb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A3U8X2F7_SALET A0A3U8X2F7_SALET]] Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.[HAMAP-Rule:MF_01646][SAAS:SAAS00971394]
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[https://www.uniprot.org/uniprot/CYSG_SALTY CYSG_SALTY] Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.<ref>PMID:14595395</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6veb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6veb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Siroheme synthase|Siroheme synthase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pennington, J M]]
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[[Category: Salmonella enterica subsp. enterica]]
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[[Category: Stroupe, M E]]
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[[Category: Pennington JM]]
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[[Category: Cysg]]
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[[Category: Stroupe ME]]
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[[Category: Tetrapyrrole biosynthesis]]
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[[Category: Transferase]]
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Current revision

Precorrin-2-bound S128A S. typhimurium siroheme synthase

PDB ID 6veb

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