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7zls
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7zls is ON HOLD Authors: Ramachandran, S., Ciulli, A., Makukhin, N. Description: co-crystal structure of SOCS2:ElonginB:ElonginC in complex with co...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13== | |
| - | + | <StructureSection load='7zls' size='340' side='right'caption='[[7zls]], [[Resolution|resolution]] 1.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zls]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JH9:[4-[(2~{S})-3-[(4-fluoranyl-3-prop-2-enyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl]+dihydrogen+phosphate'>JH9</scene></td></tr> |
| - | [[Category: Ciulli | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zls OCA], [https://pdbe.org/7zls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zls RCSB], [https://www.ebi.ac.uk/pdbsum/7zls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zls ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ciulli A]] | ||
| + | [[Category: Makukhin N]] | ||
| + | [[Category: Ramachandran S]] | ||
Current revision
co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13
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