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5lcx

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==Isopiperitenone reductase from Mentha piperita in complex with NADP==
==Isopiperitenone reductase from Mentha piperita in complex with NADP==
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<StructureSection load='5lcx' size='340' side='right' caption='[[5lcx]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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<StructureSection load='5lcx' size='340' side='right'caption='[[5lcx]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lcx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LCX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mentha_x_piperita Mentha x piperita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LCX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.709&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(-)-isopiperitenone_reductase (-)-isopiperitenone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.82 1.3.1.82] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lcx OCA], [http://pdbe.org/5lcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lcx RCSB], [http://www.ebi.ac.uk/pdbsum/5lcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lcx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lcx OCA], [https://pdbe.org/5lcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lcx RCSB], [https://www.ebi.ac.uk/pdbsum/5lcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lcx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IPIPR_MENPI IPIPR_MENPI]] Monoterpene synthase that catalyzes the specific reduction of the 1(2)-double bond of (-)-isopiperitenone to produce (+)-cis-isopulegone. Does not catalyze the reverse reaction. Unable to reduce (+)-pulegone, (+)-cis-isopulegone, (-)-menthone or the 1,2-double bond of (-)-carvone. Able to utilize NADH with 20% the efficiency of NADPH.
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[https://www.uniprot.org/uniprot/IPIPR_MENPI IPIPR_MENPI] Monoterpene synthase that catalyzes the specific reduction of the 1(2)-double bond of (-)-isopiperitenone to produce (+)-cis-isopulegone. Does not catalyze the reverse reaction. Unable to reduce (+)-pulegone, (+)-cis-isopulegone, (-)-menthone or the 1,2-double bond of (-)-carvone. Able to utilize NADH with 20% the efficiency of NADPH.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Karuppiah, V]]
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[[Category: Large Structures]]
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[[Category: Leys, D]]
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[[Category: Mentha x piperita]]
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[[Category: Scrutton, N S]]
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[[Category: Karuppiah V]]
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[[Category: Toogood, H S]]
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[[Category: Leys D]]
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[[Category: Isopiperitenone]]
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[[Category: Scrutton NS]]
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[[Category: Isopulegone]]
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[[Category: Toogood HS]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

Isopiperitenone reductase from Mentha piperita in complex with NADP

PDB ID 5lcx

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