5ld8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:56, 11 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA==
==GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA==
-
<StructureSection load='5ld8' size='340' side='right' caption='[[5ld8]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
+
<StructureSection load='5ld8' size='340' side='right'caption='[[5ld8]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ld8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LD8 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ld8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LD8 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6U5:~{N}-(1-METHYLINDAZOL-6-YL)BUTANE-1-SULFONAMIDE'>6U5</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6U5:~{N}-(1-METHYLINDAZOL-6-YL)BUTANE-1-SULFONAMIDE'>6U5</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ld8 OCA], [http://pdbe.org/5ld8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ld8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ld8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ld8 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ld8 OCA], [https://pdbe.org/5ld8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ld8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ld8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ld8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FAB1_MYCTU FAB1_MYCTU]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity).
+
[https://www.uniprot.org/uniprot/KASA_MYCTU KASA_MYCTU] Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11600501, PubMed:12023885, PubMed:12464486, PubMed:16873379, PubMed:22017312, PubMed:24108128). Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length (PubMed:12464486).<ref>PMID:11600501</ref> <ref>PMID:12023885</ref> <ref>PMID:12464486</ref> <ref>PMID:16873379</ref> <ref>PMID:22017312</ref> <ref>PMID:24108128</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5ld8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ld8" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Chung, C W]]
+
[[Category: Large Structures]]
-
[[Category: Neu, M]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Complex]]
+
[[Category: Chung CW]]
-
[[Category: Inhibitor]]
+
[[Category: Neu M]]
-
[[Category: Kasa]]
+
-
[[Category: Mycobacterium tuberculosis]]
+
-
[[Category: Transferase]]
+

Current revision

GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA

PDB ID 5ld8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ld8"
Personal tools