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5lf5

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==Myelin-associated glycoprotein (MAG) deglycosylated full extracellular domain with co-purified ligand==
==Myelin-associated glycoprotein (MAG) deglycosylated full extracellular domain with co-purified ligand==
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<StructureSection load='5lf5' size='340' side='right' caption='[[5lf5]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<StructureSection load='5lf5' size='340' side='right'caption='[[5lf5]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lf5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LF5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LF5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf5 OCA], [http://pdbe.org/5lf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lf5 RCSB], [http://www.ebi.ac.uk/pdbsum/5lf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf5 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf5 OCA], [https://pdbe.org/5lf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lf5 RCSB], [https://www.ebi.ac.uk/pdbsum/5lf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MAG_MOUSE MAG_MOUSE]] Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS.<ref>PMID:10625334</ref>
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[https://www.uniprot.org/uniprot/MAG_MOUSE MAG_MOUSE] Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS.<ref>PMID:10625334</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Janssen, B J.C]]
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[[Category: Large Structures]]
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[[Category: Pronker, M F]]
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[[Category: Mus musculus]]
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[[Category: Cell adhesion]]
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[[Category: Janssen BJC]]
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[[Category: Myelin]]
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[[Category: Pronker MF]]
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[[Category: Signaling]]
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Current revision

Myelin-associated glycoprotein (MAG) deglycosylated full extracellular domain with co-purified ligand

PDB ID 5lf5

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