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5lfq

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==Crystal Structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis (space group P3)==
==Crystal Structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis (space group P3)==
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<StructureSection load='5lfq' size='340' side='right' caption='[[5lfq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='5lfq' size='340' side='right'caption='[[5lfq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lfq]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LFQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lfq]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LFQ FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.503&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5lfj|5lfj]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lfq OCA], [http://pdbe.org/5lfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lfq RCSB], [http://www.ebi.ac.uk/pdbsum/5lfq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lfq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lfq OCA], [https://pdbe.org/5lfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lfq RCSB], [https://www.ebi.ac.uk/pdbsum/5lfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lfq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU]] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref>
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[https://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ban, N]]
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[[Category: Large Structures]]
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[[Category: Boehringer, D]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bolten, M]]
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[[Category: Ban N]]
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[[Category: Delley, C L]]
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[[Category: Boehringer D]]
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[[Category: Leibundgut, M]]
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[[Category: Bolten M]]
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[[Category: Weber-Ban, E]]
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[[Category: Delley CL]]
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[[Category: Dodecamer]]
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[[Category: Leibundgut M]]
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[[Category: Four-helix bundle]]
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[[Category: Weber-Ban E]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis (space group P3)

PDB ID 5lfq

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