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5lgb

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==Crystal structure of murine N1-acetylpolyamine oxidase in complex with MDL72527==
==Crystal structure of murine N1-acetylpolyamine oxidase in complex with MDL72527==
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<StructureSection load='5lgb' size='340' side='right' caption='[[5lgb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5lgb' size='340' side='right'caption='[[5lgb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lgb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LGB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lgb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LGB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YU:FAD-MDL72527+adduct'>6YU</scene>, <scene name='pdbligand=MD2:N,N-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE'>MD2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgb OCA], [http://pdbe.org/5lgb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lgb RCSB], [http://www.ebi.ac.uk/pdbsum/5lgb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgb ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6YU:FAD-MDL72527+adduct'>6YU</scene>, <scene name='pdbligand=MD2:N,N-BIS(2,3-BUTADIENYL)-1,4-BUTANE-DIAMINE'>MD2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgb OCA], [https://pdbe.org/5lgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lgb RCSB], [https://www.ebi.ac.uk/pdbsum/5lgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAOX_MOUSE PAOX_MOUSE]] Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
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[https://www.uniprot.org/uniprot/PAOX_MOUSE PAOX_MOUSE] Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aagaard, A]]
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[[Category: Large Structures]]
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[[Category: Barlind, L]]
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[[Category: Mus musculus]]
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[[Category: Sjogren, T]]
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[[Category: Aagaard A]]
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[[Category: Snijder, A]]
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[[Category: Barlind L]]
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[[Category: Wassvik, C]]
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[[Category: Sjogren T]]
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[[Category: Flavin amine oxidase]]
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[[Category: Snijder A]]
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[[Category: Oxidoreductase]]
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[[Category: Wassvik C]]

Current revision

Crystal structure of murine N1-acetylpolyamine oxidase in complex with MDL72527

PDB ID 5lgb

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