Retinoid isomerohydrolase

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== Structural highlights ==
== Structural highlights ==
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The <scene name='74/749418/Cv/4'>inhibitor RPE65 drug amixutat binds in the active site</scene> near the enzyme's membrane-embedded substrate-entry point. The <scene name='74/749418/Cv/3'>catalytic Fe+2 is 5-coordinated</scene><ref>PMID:25894083</ref>.
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The <scene name='74/749418/Cv/5'>inhibitor RPE65 drug '''emixustat''' binds in the active site</scene> near the enzyme's membrane-embedded substrate-entry point. The <scene name='74/749418/Cv/6'>catalytic Fe+2 is 5-coordinated</scene><ref>PMID:25894083</ref>.
</StructureSection>
</StructureSection>
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==3D structures of resolvase==
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==3D structures of retinoid isomerohydrolase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[4f2z]], [[4f30]], [[4f3a]], [[4f3d]], [[3kvc]], [[3fsn]] – bRPE65 - bovine<br />
[[4f2z]], [[4f30]], [[4f3a]], [[4f3d]], [[3kvc]], [[3fsn]] – bRPE65 - bovine<br />
[[4ryx]], [[4ryy]], [[4ryz]], [[4rsc]] – bRPE65 + emixustat <br />
[[4ryx]], [[4ryy]], [[4ryz]], [[4rsc]] – bRPE65 + emixustat <br />
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[[7k88]] – bRPE65 + emixustat derivative<br />
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[[7k89]], [[7l0e]] – bRPE65 + emixustat derivative + palmitate<br />
[[4zhk]], [[4rse]] – bRPE65 + MB-200<br />
[[4zhk]], [[4rse]] – bRPE65 + MB-200<br />
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[[5ul5]] - bRPE65 + MB-004 + palmitate<br />
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[[8doc]] - bRPE65 + MB-003 + palmitate<br />
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[[5ul5]], [[7k8g]] - bRPE65 + MB-004 + palmitate<br />
[[5ulg]] - bRPE65 + MB-008 + palmitate<br />
[[5ulg]] - bRPE65 + MB-008 + palmitate<br />

Current revision

Bovine RPE65 complex with palmitate, amixustat and Fe+2 ion (PDB code 4rsc)

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3D structures of retinoid isomerohydrolase

Updated on 12-October-2023

4f2z, 4f30, 4f3a, 4f3d, 3kvc, 3fsn – bRPE65 - bovine
4ryx, 4ryy, 4ryz, 4rsc – bRPE65 + emixustat
7k88 – bRPE65 + emixustat derivative
7k89, 7l0e – bRPE65 + emixustat derivative + palmitate
4zhk, 4rse – bRPE65 + MB-200
8doc - bRPE65 + MB-003 + palmitate
5ul5, 7k8g - bRPE65 + MB-004 + palmitate
5ulg - bRPE65 + MB-008 + palmitate

References

  1. ↑ Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 3;281(5):2835-40. Epub 2005 Nov 30. PMID:16319067 doi:http://dx.doi.org/10.1074/jbc.M508903200
  2. ↑ Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun, 15. PMID:26075817 doi:http://dx.doi.org/10.1172/JCI80950
  3. ↑ Cai X, Conley SM, Naash MI. RPE65: role in the visual cycle, human retinal disease, and gene therapy. Ophthalmic Genet. 2009 Jun;30(2):57-62. doi: 10.1080/13816810802626399. PMID:19373675 doi:http://dx.doi.org/10.1080/13816810802626399
  4. ↑ Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr, 20. PMID:25894083 doi:http://dx.doi.org/10.1038/nchembio.1799

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