8fe5

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'''Unreleased structure'''
 
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The entry 8fe5 is ON HOLD until Paper Publication
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==Structure of J-PKAc chimera complexed with Aplithianine B==
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<StructureSection load='8fe5' size='340' side='right'caption='[[8fe5]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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Authors: Du, L., Wilson, B.A.P., Li, N., Martinez Fiesco, J.A., Dalilian, M., Wang, D., Smith, E.A., Wamiru, A., Goncharova, E.I., Zhang, P., O''Keefe, B.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fe5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FE5 FirstGlance]. <br>
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Description: Structure of J-PKAc chimera complexed with Aplithianine B
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=XTT:6-[(6P)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7,9-dihydro-8H-purin-8-one'>XTT</scene></td></tr>
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[[Category: Martinez Fiesco, J.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fe5 OCA], [https://pdbe.org/8fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fe5 ProSAT]</span></td></tr>
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[[Category: Zhang, P]]
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</table>
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[[Category: Wang, D]]
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== Function ==
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[[Category: Dalilian, M]]
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[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
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[[Category: Goncharova, E.I]]
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__TOC__
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[[Category: Wamiru, A]]
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</StructureSection>
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[[Category: Wilson, B.A.P]]
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[[Category: Homo sapiens]]
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[[Category: Du, L]]
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[[Category: Large Structures]]
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[[Category: O''Keefe, B.R]]
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[[Category: Dalilian M]]
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[[Category: Li, N]]
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[[Category: Du L]]
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[[Category: Smith, E.A]]
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[[Category: Goncharova EI]]
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[[Category: Li N]]
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[[Category: Martinez Fiesco JA]]
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[[Category: O'Keefe BR]]
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[[Category: Smith EA]]
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[[Category: Wamiru A]]
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[[Category: Wang D]]
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[[Category: Wilson BAP]]
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[[Category: Zhang P]]

Revision as of 14:05, 18 October 2023

Structure of J-PKAc chimera complexed with Aplithianine B

PDB ID 8fe5

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