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8ia2

From Proteopedia

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(New page: '''Unreleased structure''' The entry 8ia2 is ON HOLD until Paper Publication Authors: Yadav, M.K., Yadav, R., Maharana, J., Banerjee, R., Shukla, A.K., Gati, C. Description: Structure ...)
Current revision (14:08, 18 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ia2 is ON HOLD until Paper Publication
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==Structure of C5a bound human C5aR1 in complex with Go (Composite map)==
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<StructureSection load='8ia2' size='340' side='right'caption='[[8ia2]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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Authors: Yadav, M.K., Yadav, R., Maharana, J., Banerjee, R., Shukla, A.K., Gati, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ia2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IA2 FirstGlance]. <br>
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Description: Structure of C5a bound human C5aR1 in complex with Go (Composite map)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.21&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ia2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ia2 OCA], [https://pdbe.org/8ia2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ia2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ia2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ia2 ProSAT]</span></td></tr>
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[[Category: Shukla, A.K]]
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</table>
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[[Category: Yadav, R]]
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== Function ==
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[[Category: Yadav, M.K]]
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[https://www.uniprot.org/uniprot/C5AR1_HUMAN C5AR1_HUMAN] Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).<ref>PMID:10636859</ref> <ref>PMID:15153520</ref> <ref>PMID:1847994</ref> <ref>PMID:7622471</ref> <ref>PMID:8182049</ref> <ref>PMID:9553099</ref>
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[[Category: Maharana, J]]
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== References ==
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[[Category: Banerjee, R]]
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<references/>
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[[Category: Gati, C]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Banerjee R]]
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[[Category: Gati C]]
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[[Category: Maharana J]]
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[[Category: Shukla AK]]
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[[Category: Yadav MK]]
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[[Category: Yadav R]]

Current revision

Structure of C5a bound human C5aR1 in complex with Go (Composite map)

PDB ID 8ia2

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