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1nih
From Proteopedia
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[[Image:1nih.gif|left|200px]] | [[Image:1nih.gif|left|200px]] | ||
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'''Structure of deoxy-quaternary haemoglobin with liganded beta subunits''' | '''Structure of deoxy-quaternary haemoglobin with liganded beta subunits''' | ||
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[[Category: Liddington, B.]] | [[Category: Liddington, B.]] | ||
[[Category: Luisi, B.]] | [[Category: Luisi, B.]] | ||
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Revision as of 23:34, 2 May 2008
Structure of deoxy-quaternary haemoglobin with liganded beta subunits
Overview
We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin.
About this Structure
1NIH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of deoxy-quaternary haemoglobin with liganded beta subunits., Luisi B, Liddington B, Fermi G, Shibayama N, J Mol Biol. 1990 Jul 5;214(1):7-14. PMID:2370669 Page seeded by OCA on Sat May 3 02:34:31 2008
