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6w25

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Current revision (14:15, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6w25' size='340' side='right'caption='[[6w25]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='6w25' size='340' side='right'caption='[[6w25]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6w25]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W25 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W25 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6w25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W25 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MC4R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w25 OCA], [https://pdbe.org/6w25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w25 RCSB], [https://www.ebi.ac.uk/pdbsum/6w25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w25 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w25 OCA], [http://pdbe.org/6w25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w25 RCSB], [http://www.ebi.ac.uk/pdbsum/6w25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w25 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN]] Obesity due to melanocortin 4 receptor deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Obesity due to melanocortin 4 receptor deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN]] Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).<ref>PMID:12646665</ref> <ref>PMID:25163632</ref>
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[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).<ref>PMID:12646665</ref> <ref>PMID:25163632</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6w25" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6w25" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Alice Clark/BRCT|Alice Clark/BRCT]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Burdsall, K]]
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[[Category: Pyrococcus abyssi GE5]]
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[[Category: Chen, V]]
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[[Category: Synthetic construct]]
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[[Category: Cone, R D]]
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[[Category: Burdsall K]]
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[[Category: Gimenez, L E]]
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[[Category: Chen V]]
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[[Category: Han, G W]]
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[[Category: Cone RD]]
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[[Category: Hernandez, C C]]
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[[Category: Gimenez LE]]
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[[Category: McClary, K]]
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[[Category: Han GW]]
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[[Category: Millhauser, G L]]
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[[Category: Hernandez CC]]
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[[Category: Mittal, S R]]
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[[Category: McClary K]]
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[[Category: Peisley, A]]
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[[Category: Millhauser GL]]
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[[Category: Stauch, B]]
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[[Category: Mittal SR]]
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[[Category: Stevens, R C]]
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[[Category: Peisley A]]
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[[Category: Stevens, S N]]
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[[Category: Stauch B]]
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[[Category: Wein, A H]]
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[[Category: Stevens RC]]
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[[Category: Williams, S Y]]
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[[Category: Stevens SN]]
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[[Category: Wu, L]]
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[[Category: Wein AH]]
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[[Category: Wu, Y]]
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[[Category: Williams SY]]
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[[Category: Yu, J]]
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[[Category: Wu L]]
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[[Category: Zhao, S]]
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[[Category: Wu Y]]
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[[Category: Ca++ cofactor]]
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[[Category: Yu J]]
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[[Category: Gpcr]]
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[[Category: Zhao S]]
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[[Category: Lcp]]
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[[Category: Melanocortin-4 receptor]]
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[[Category: Membrane protein]]
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[[Category: Pgs fusion]]
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[[Category: Shu9119]]
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Current revision

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119

PDB ID 6w25

Drag the structure with the mouse to rotate

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