1njg

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[[Image:1njg.gif|left|200px]]
[[Image:1njg.gif|left|200px]]
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{{Structure
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|PDB= 1njg |SIZE=350|CAPTION= <scene name='initialview01'>1njg</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1njg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DnaX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1njg| PDB=1njg | SCENE= }}
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|RELATEDENTRY=[[1njf|1NJF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1njg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1njg OCA], [http://www.ebi.ac.uk/pdbsum/1njg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1njg RCSB]</span>
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'''Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit'''
'''Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit'''
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[[Category: Podobnik, M.]]
[[Category: Podobnik, M.]]
[[Category: Weitze, T F.]]
[[Category: Weitze, T F.]]
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[[Category: aaa+ atpase domain]]
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[[Category: Aaa+ atpase domain]]
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[[Category: rossman-like fold]]
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[[Category: Rossman-like fold]]
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[[Category: Sensor 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:36:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:31:15 2008''
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Revision as of 23:36, 2 May 2008

Image:1njg.gif

Template:STRUCTURE 1njg

Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit


Overview

Sliding clamps are loaded onto DNA by ATP-driven clamp loader complexes. The structure of the E. coli clamp loader in a nucleotide-free state has been determined previously. We now report crystal structures of a truncated form of the isolated gamma-ATPase subunit, gamma(1-243), of the E. coli clamp loader, in nucleotide-free and bound forms. The gamma subunit adopts a defined conformation when empty, in which the nucleotide binding site is blocked. The binding of either ATPgammaS or ADP, which are shown to bind with equal affinity to gamma(1-243), induces a change in the relative orientation of the two domains such that nucleotides can be accommodated. This change would break one of the gamma:gamma interfaces seen in the empty clamp loader complex, and may represent one step in the activation process.

About this Structure

1NJG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit., Podobnik M, Weitze TF, O'Donnell M, Kuriyan J, Structure. 2003 Mar;11(3):253-63. PMID:12623013 Page seeded by OCA on Sat May 3 02:36:21 2008

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