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7kiq

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Current revision (15:25, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7kiq' size='340' side='right'caption='[[7kiq]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
<StructureSection load='7kiq' size='340' side='right'caption='[[7kiq]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7kiq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KIQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7kiq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KIQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.523&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7kih|7kih]], [[7kil|7kil]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lpin2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kiq OCA], [https://pdbe.org/7kiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kiq RCSB], [https://www.ebi.ac.uk/pdbsum/7kiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kiq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kiq OCA], [https://pdbe.org/7kiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kiq RCSB], [https://www.ebi.ac.uk/pdbsum/7kiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kiq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LPIN2_MOUSE LPIN2_MOUSE]] Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.<ref>PMID:17158099</ref> <ref>PMID:19136718</ref> <ref>PMID:19717560</ref>
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[https://www.uniprot.org/uniprot/LPIN2_MOUSE LPIN2_MOUSE] Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.<ref>PMID:17158099</ref> <ref>PMID:19136718</ref> <ref>PMID:19717560</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Airola, M V]]
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[[Category: Airola MV]]
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[[Category: Gu, W]]
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[[Category: Gu W]]
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[[Category: Yang, J W]]
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[[Category: Yang JW]]
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[[Category: Dimer]]
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[[Category: Lipid binding protein]]
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[[Category: Lipin]]
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[[Category: M-lip]]
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Current revision

Crystal structure of the mouse lipin-2 M-Lip domain

PDB ID 7kiq

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