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7lpk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7lpk is ON HOLD Authors: Chan, A., Schonbrunn, E. Description: Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112 [[Category...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112== | |
| - | + | <StructureSection load='7lpk' size='340' side='right'caption='[[7lpk]], [[Resolution|resolution]] 1.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7lpk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LPK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=Y9P:4-chloranyl-2-methyl-5-[[(3~{R})-pyrrolidin-3-yl]amino]pyridazin-3-one'>Y9P</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lpk OCA], [https://pdbe.org/7lpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lpk RCSB], [https://www.ebi.ac.uk/pdbsum/7lpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lpk ProSAT]</span></td></tr> |
| - | [[Category: Chan | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chan A]] | ||
| + | [[Category: Schonbrunn E]] | ||
Current revision
Crystal structure of BPTF bromodomain in complex with inhibitor HZ-03-112
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