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7mwk

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(New page: '''Unreleased structure''' The entry 7mwk is ON HOLD Authors: Liu, K., Dong, A., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC) Description: Crystal str...)
Current revision (16:20, 18 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7mwk is ON HOLD
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==Crystal structure of MBD2 with DNA==
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<StructureSection load='7mwk' size='340' side='right'caption='[[7mwk]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7mwk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.453&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwk OCA], [https://pdbe.org/7mwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwk RCSB], [https://www.ebi.ac.uk/pdbsum/7mwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
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Authors: Liu, K., Dong, A., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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Description: Crystal structure of MBD2 with DNA
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Arrowsmith, C.H]]
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__TOC__
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[[Category: Dong, A]]
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</StructureSection>
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[[Category: Liu, K]]
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[[Category: Homo sapiens]]
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[[Category: Min, J]]
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[[Category: Large Structures]]
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[[Category: Edwards, A.M]]
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[[Category: Synthetic construct]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Liu K]]
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[[Category: Min J]]

Current revision

Crystal structure of MBD2 with DNA

PDB ID 7mwk

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