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7r9f
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7r9f is ON HOLD Authors: Doyle, L.A., Stoddard, B.L. Description: Wild-type yeast Pseudouridine Synthase bound to 5-Fluorouracil RNA [[Category: Un...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Wild-type yeast Pseudouridine Synthase, PUS1, bound to 5-Fluorouracil RNA== | |
| + | <StructureSection load='7r9f' size='340' side='right'caption='[[7r9f]], [[Resolution|resolution]] 2.89Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7r9f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R9F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r9f OCA], [https://pdbe.org/7r9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r9f RCSB], [https://www.ebi.ac.uk/pdbsum/7r9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r9f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PUS1_YEAST PUS1_YEAST] Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr) (PubMed:9671058, PubMed:10356324, PubMed:25219674). Catalyzes pseudouridylation at position 44 in U2 snRNA (PubMed:25219674). Also catalyzes pseudouridylation of mRNAs (PubMed:25219674, PubMed:31477916).<ref>PMID:10356324</ref> <ref>PMID:25219674</ref> <ref>PMID:31477916</ref> <ref>PMID:9671058</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Doyle | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Doyle LA]] | ||
| + | [[Category: Stoddard BL]] | ||
Current revision
Wild-type yeast Pseudouridine Synthase, PUS1, bound to 5-Fluorouracil RNA
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