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7rxw

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Current revision (16:40, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7rxw' size='340' side='right'caption='[[7rxw]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
<StructureSection load='7rxw' size='340' side='right'caption='[[7rxw]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7rxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RXW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7rxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RXW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PN:IMIDODIPHOSPHORIC+ACID'>2PN</scene>, <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7l1a|7l1a]], [[7rxv|7rxv]], [[7rxx|7rxx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PN:IMIDODIPHOSPHORIC+ACID'>2PN</scene>, <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rxw OCA], [https://pdbe.org/7rxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rxw RCSB], [https://www.ebi.ac.uk/pdbsum/7rxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rxw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rxw OCA], [https://pdbe.org/7rxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rxw RCSB], [https://www.ebi.ac.uk/pdbsum/7rxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rxw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
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[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7rxw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7rxw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine adenosyltransferase]]
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[[Category: Fedorov E]]
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[[Category: Fedorov, E]]
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[[Category: Ghosh A]]
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[[Category: Ghosh, A]]
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[[Category: Niland CN]]
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[[Category: Niland, C N]]
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[[Category: Schramm VL]]
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[[Category: Schramm, V L]]
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[[Category: Enzyme mechanism]]
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[[Category: Inhibitor]]
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[[Category: Sam synthetase]]
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[[Category: Transferase]]
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[[Category: Transferase-inhibitor complex]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Transition state]]
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Current revision

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor imido-diphosphate (PNP)

PDB ID 7rxw

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OCA

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