This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7sb7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:48, 18 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7sb7' size='340' side='right'caption='[[7sb7]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='7sb7' size='340' side='right'caption='[[7sb7]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7sb7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SB7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7sb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SB7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QI:({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic+acid'>8QI</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6471663&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QI:({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic+acid'>8QI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sb7 OCA], [https://pdbe.org/7sb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sb7 RCSB], [https://www.ebi.ac.uk/pdbsum/7sb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sb7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sb7 OCA], [https://pdbe.org/7sb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sb7 RCSB], [https://www.ebi.ac.uk/pdbsum/7sb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sb7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
+
[https://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 7sb7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7sb7" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Hypoxanthine phosphoribosyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Guddat, L W]]
+
[[Category: Trypanosoma brucei brucei]]
-
[[Category: Keough, D T]]
+
[[Category: Guddat LW]]
-
[[Category: Complex]]
+
[[Category: Keough DT]]
-
[[Category: Inhibitor]]
+
-
[[Category: Phosphonate]]
+
-
[[Category: Purine]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

PDB ID 7sb7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7sb7"
Personal tools