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7sgi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14== | |
| + | <StructureSection load='7sgi' size='340' side='right'caption='[[7sgi]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7sgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SGI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DL:5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide'>9DL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sgi OCA], [https://pdbe.org/7sgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sgi RCSB], [https://www.ebi.ac.uk/pdbsum/7sgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sgi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HDA10_DANRE HDA10_DANRE] Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Has a very weak lysine deacetylase, if any (PubMed:28516954).<ref>PMID:28516954</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Christianson | + | __TOC__ |
| - | [[Category: Herbst-Gervasoni | + | </StructureSection> |
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Christianson DW]] | ||
| + | [[Category: Herbst-Gervasoni CJ]] | ||
Current revision
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14
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