7t39
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7t39 is ON HOLD Authors: Zeng, H., Dong, A., Hutchinson, A., Seitova, A., Li, Y., Gao, Y.D., Schneider, S., Siliphaivanh, P., Sloman, D., Nicholson,...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of human PRMT9 in complex with MT221 inhibitor== | |
| - | + | <StructureSection load='7t39' size='340' side='right'caption='[[7t39]], [[Resolution|resolution]] 2.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T39 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJB:7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine'>EJB</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t39 OCA], [https://pdbe.org/7t39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t39 RCSB], [https://www.ebi.ac.uk/pdbsum/7t39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t39 ProSAT]</span></td></tr> |
| - | [[Category: Arrowsmith | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Dong | + | [https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Nicholson | + | [[Category: Brown PJ]] |
| - | [[Category: | + | [[Category: Dong A]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: Siliphaivanh | + | [[Category: Fischer C]] |
| - | [[Category: | + | [[Category: Gao YD]] |
| - | [[Category: | + | [[Category: Halabelian L]] |
| + | [[Category: Hicks J]] | ||
| + | [[Category: Hutchinson A]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Nicholson B]] | ||
| + | [[Category: Schneider S]] | ||
| + | [[Category: Seitova A]] | ||
| + | [[Category: Siliphaivanh P]] | ||
| + | [[Category: Sloman D]] | ||
| + | [[Category: Zeng H]] | ||
Current revision
Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Brown PJ | Dong A | Edwards AM | Fischer C | Gao YD | Halabelian L | Hicks J | Hutchinson A | Li Y | Nicholson B | Schneider S | Seitova A | Siliphaivanh P | Sloman D | Zeng H
