7t39

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m (Protected "7t39" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7t39 is ON HOLD
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==Co-crystal structure of human PRMT9 in complex with MT221 inhibitor==
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<StructureSection load='7t39' size='340' side='right'caption='[[7t39]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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Authors: Zeng, H., Dong, A., Hutchinson, A., Seitova, A., Li, Y., Gao, Y.D., Schneider, S., Siliphaivanh, P., Sloman, D., Nicholson, B., Fischer, C., Hicks, J., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7t39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T39 FirstGlance]. <br>
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Description: Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJB:7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine'>EJB</scene></td></tr>
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[[Category: Hutchinson, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t39 OCA], [https://pdbe.org/7t39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t39 RCSB], [https://www.ebi.ac.uk/pdbsum/7t39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t39 ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Seitova, A]]
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== Function ==
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[[Category: Dong, A]]
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[https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref>
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[[Category: Hicks, J]]
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== References ==
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[[Category: Li, Y]]
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<references/>
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[[Category: Halabelian, L]]
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__TOC__
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[[Category: Brown, P.J]]
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</StructureSection>
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[[Category: Fischer, C]]
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[[Category: Homo sapiens]]
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[[Category: Zeng, H]]
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[[Category: Large Structures]]
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[[Category: Schneider, S]]
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[[Category: Arrowsmith CH]]
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[[Category: Nicholson, B]]
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[[Category: Brown PJ]]
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[[Category: Sloman, D]]
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[[Category: Dong A]]
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[[Category: Edwards, A.M]]
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[[Category: Edwards AM]]
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[[Category: Siliphaivanh, P]]
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[[Category: Fischer C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Gao YD]]
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[[Category: Gao, Y.D]]
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[[Category: Halabelian L]]
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[[Category: Hicks J]]
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[[Category: Hutchinson A]]
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[[Category: Li Y]]
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[[Category: Nicholson B]]
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[[Category: Schneider S]]
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[[Category: Seitova A]]
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[[Category: Siliphaivanh P]]
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[[Category: Sloman D]]
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[[Category: Zeng H]]

Current revision

Co-crystal structure of human PRMT9 in complex with MT221 inhibitor

PDB ID 7t39

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