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2y9k

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[[Image:2y9k.png|left|200px]]
 
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{{STRUCTURE_2y9k| PDB=2y9k | SCENE= }}
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==Three-dimensional model of Salmonella's needle complex at subnanometer resolution==
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<SX load='2y9k' size='340' side='right' viewer='molstar' caption='[[2y9k]], [[Resolution|resolution]] 8.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y9k]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y9K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y9k OCA], [https://pdbe.org/2y9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y9k RCSB], [https://www.ebi.ac.uk/pdbsum/2y9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y9k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCTC1_SALTY SCTC1_SALTY] Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:9786184, PubMed:27974800, PubMed:30242280). Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:9786184, PubMed:21385715, PubMed:27974800, PubMed:30242280).<ref>PMID:21385715</ref> <ref>PMID:27974800</ref> <ref>PMID:30242280</ref> <ref>PMID:9786184</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly.
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===THREE-DIMENSIONAL MODEL OF SALMONELLA'S NEEDLE COMPLEX AT SUBNANOMETER RESOLUTION===
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Three-dimensional model of Salmonella's needle complex at subnanometer resolution.,Schraidt O, Marlovits TC Science. 2011 Mar 4;331(6021):1192-5. PMID:21385715<ref>PMID:21385715</ref>
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{{ABSTRACT_PUBMED_21385715}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2y9k" style="background-color:#fffaf0;"></div>
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[[2y9k]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y9K OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:021385715</ref><references group="xtra"/>
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</SX>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Large Structures]]
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[[Category: Marlovits, T C.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Schraidt, O.]]
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[[Category: Marlovits TC]]
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[[Category: C15 fold]]
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[[Category: Schraidt O]]
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[[Category: Outer membrane ring]]
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[[Category: Protein transport]]
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[[Category: Secretin family]]
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[[Category: Type iii secretion system]]
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Current revision

Three-dimensional model of Salmonella's needle complex at subnanometer resolution

2y9k, resolution 8.30Å

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