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Retroviral integrase 3D structures

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Current revision (06:49, 19 October 2023) (edit) (undo)
 
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*Human spumaretrovirus integrase
*Human spumaretrovirus integrase
-
**[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]], [[5uoq]], [[5uop]], [[5no1]], [[5mmb]], [[5mma]], [[5fro]], [[5frm]], [[4ztj]], [[4ztf]] – IN + DNA – human spumaretrovirus<br />
+
**[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]], [[5uoq]], [[5uop]], [[5no1]], [[5mmb]], [[5mma]], [[5fro]], [[5frm]], [[4ztj]], [[4ztf]] – intasome – human spumaretrovirus<br />
-
**[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br />
+
**[[3l2u]], [[3l2v]], [[3l2w]],[[3oya]], [[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[4be0]], [[4be1]], [[4ztf]], [[4ztj]], [[5frm]], [[5frn]], [[5fro]], [[5mma]], [[5mmb]], [[5no1]], [[5uop]], [[5uoq]], [[7adu]], [[7adv]] – intasome + inhibitor<br />
-
**[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain
+
**[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain<br />
 +
**[[6rny]] – intasome + nucleosome – Cryo EM<br />
 +
**[[3s3m]], [[4e7h]] – IN + DNA <br />
*Bovine immunodeficiency virus integrase
*Bovine immunodeficiency virus integrase
Line 14: Line 16:
**[[3kkr]], [[3kks]] – IN catalytic core domain – BIV
**[[3kkr]], [[3kks]] – IN catalytic core domain – BIV
-
*Human immunodeficiency virus 1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359
+
*Human immunodeficiency virus 1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359; intasome 1-288 + DNA
-
**[[5oi5]], [[5oi3]], [[5oi2]], [[1itg]], [[6jcg]], [[6jcf]] – IN catalytic core domain <br />
+
**[[6u8q]], [[6vdk]] – intasome – Cryo EM <br />
-
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]], [[5jl4]] - IN catalytic core domain (mutant) – HIV-1<br />
+
**[[1itg]], [[4dmn]], [[5oi5]], [[5oi3]], [[5oi2]], [[6jcg]], [[6jcf]], [[6vrg]], [[8wf7]] – IN catalytic core domain <br />
 +
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]], [[5jl4]], [[6l0c]], [[6vrg]] - IN catalytic core domain (mutant) – HIV-1<br />
 +
**[[6t6e]], [[6t6i]], [[6t6j]] – IN catalytic C-terminal domain <br />
**[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br />
**[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br />
**[[1k6y]] - IN N-terminal + catalytic core domain<br />
**[[1k6y]] - IN N-terminal + catalytic core domain<br />
Line 26: Line 30:
**[[1qmc]] – IN DBD - NMR<br />
**[[1qmc]] – IN DBD - NMR<br />
**[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]], [[1qs4]] - IN CCD domain (mutant) + lens epithelium-derived growth factor <br />
**[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]], [[1qs4]] - IN CCD domain (mutant) + lens epithelium-derived growth factor <br />
-
**[[6ex9]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[4o0j]], [[1hyv]], [[1hyz]] – IN catalytic core domain + inhibitor <br />
+
**[[8cbt]], [[8cbv]] - IN CCD domain + inhibitor <br />
-
**[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]], [[4ojr]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[5hot]], [[4tsx]], [[4ovl]], [[4ojr]], [[4o5b]], [[4o55]], [[4nyf]], [[6nuj]], [[6ncj]], [[6eb2]], [[6eb1]] - IN core domain (mutant) + inhibitor<br />
+
**[[3ao5]] - IN 765-927 + inhibitor <br />
 +
**[[4ahr]], [[4ahs]], [[4aht]], [[4ahu]] - IN CCD domain (mutant) + inhibitor <br />
 +
**[[1hyv]], [[1hyz]], [[4cer]], [[4chp]], [[4chy]], [[4o0j]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[6ex9]], [[6um8]], [[6vkh]], [[6vlh]], [[6vlm]], [[6vqs]], [[6vx2]], [[6w0u]], [[6w42]], [[6wc8]], [[6we7]], [[7d83]], [[7ke0]], [[7l1p]], [[7l23]], [[7l2y]], [[7lqp]], [[7rq0]], [[7sia]], [[7t9h]], [[7t9o]], [[7u2u]], [[7uoq]], [[7wce]], [[8bv2]], [[8cbr]] – IN catalytic core domain + inhibitor <br />
 +
**[[1qs4]], [[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[3zsv]], [[3zsx]], [[3zt2]], [[4ceb]], [[4ces]], [[4cf9]], [[4chq]], [[4cj4]], [[4cjt]], [[4cju]], [[4e1m]], [[4e1n]], [[4jlh]], [[4lh4]], [[4nyf]], [[4o55]], [[4o5b]], [[4ojr]], [[4ovl]], [[4tsx]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[5hot]], [[6eb1]], [[6eb2]], [[6lmi]], [[6lmq]], [[6ncj]], [[6nuj]], [[6vka]], [[7ue1]], [[8ct7]], [[8d3s]] - IN core domain (mutant) + inhibitor<br />
 +
**[[8a1p]], [[8cbs]], [[8cbu]], [[8cta]] – IN catalytic core+ C-terminal domains + inhibitor <br />
 +
**[[8a1q]] – IN catalytic core+ C-terminal domains + drug <br />
**[[5tc2]] – IN C terminal <br />
**[[5tc2]] – IN C terminal <br />
**[[5eu7]] – IN catalytic core domain + antibody <br />
**[[5eu7]] – IN catalytic core domain + antibody <br />
-
**[[4y1d]], [[4y1c]] – IN catalytic core domain + peptide <br />
+
**[[3wne]], [[3wnh]], [[4y1d]], [[4y1c]] – IN catalytic core domain + peptide <br />
 +
**[[8fn7]], [[8fnd]], [[8fng]], [[8fnh]], [[8fnj]], [[8fnl]], [[8fnm]], [[8fnn]], [[8fno]], [[8fnp]], [[8fnq]] – IN intasome (mutant) + drug <br />
*Human immunodeficiency virus 2 integrase
*Human immunodeficiency virus 2 integrase
 +
**[[6qbt]] – IN catalytic core domain <br />
**[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br />
**[[3f9k]] - IN N-terminal + catalytic core domain + LEDGF IBD – HIV-2<br />
**[[1e0e]] - IN N-terminal – NMR
**[[1e0e]] - IN N-terminal – NMR
 +
 +
*Human T-cell leukemia virus
 +
 +
**[[6qbv]], [[6qbw]] – IN catalytic core domain <br />
 +
**[[6tju]] – IN C-terminal domain <br />
*Moloney murine leukemia virus integrase
*Moloney murine leukemia virus integrase
-
**[[3nnq]], [[4nzg]] – IN N-terminal – MOMLV
+
**[[3nnq]], [[4nzg]] – IN N-terminal – MOMLV<br />
 +
**[[2m9u]] – IN C-terminal domain - NMR<br />
 +
**[[7jyz]] – IN C-terminal domain + hBrd3 - NMR<br />
*Maedi Visna virus integrase
*Maedi Visna virus integrase
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**[[5t3a]] – IN <br />
**[[5t3a]] – IN <br />
**[[5llj]] – IN C terminal<br />
**[[5llj]] – IN C terminal<br />
-
**[[5m0r]], [[5m0q]] – IN + DNA – Cryo EM<br />
+
**[[5m0r]], [[7zpp]], [[7u32]] – intasome – Cryo EM<br />
*Simian immunodeficiency virus integrase
*Simian immunodeficiency virus integrase
-
**[[1c6v]] – IN catalytic domain + DNA binding domain - SIV
+
**[[1c6v]] – IN catalytic domain (mutant) + DNA binding domain - SIV <br />
 +
**[[6rwl]] – intasome – Cryo EM<br />
 +
**[[6rwo]] – intasome (mutant) + drug – Cryo EM<br />
 +
 
 +
*Simian T-cell lymphotropic virus
 +
 
 +
**[[6rwl]] – intasome + PP2A regulatory subunit – Cryo EM<br />
 +
**[[7ouf]], [[7ouh]] – intasome (mutant) + B56 + DNA – Cryo EM<br />
 +
**[[7oug]] – intasome (mutant) + B56 + DNA + drug – Cryo EM<br />
*Feline immunodeficiency virus integrase
*Feline immunodeficiency virus integrase
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**[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br />
**[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br />
**[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor<br />
**[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor<br />
-
**[[5ejk]] – IN + DNA + gag-pro-pol polyprotein <br />
+
**[[5ejk]] – intasome + gag-pro-pol polyprotein <br />
 +
**[[7ku7]], [[7kui]], [[8e14]] – intasome – Cryo EM<br />
 +
**[[7jn3]] – intasome (mutant) + drug – Cryo EM<br />
*Avian sarcoma virus integrase
*Avian sarcoma virus integrase
**[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV
**[[1cxq]], [[1cxu]], [[1cz9]], [[1czb]], [[1asu]], [[1asv]], [[1asw]] - IN catalytic core domain (mutant) – ASV
 +
 +
*Mouse mammary tumor virus
 +
 +
**[[5cz1]] – IN catalytic domain 1487-1648<br />
 +
**[[7usf]], [[7ut1]] – IN 1437-1755 + DNA – Cryo EM<br />
 +
 +
*Sulfolobus spindle-shaped virus
 +
 +
**[[3vcf]] – IN C-terminal catalytic domain <br />
*Bacterial integrase
*Bacterial integrase
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**[[3jtz]] – IN arm-type binding domain – ''Yersinia pestis''<br />
**[[3jtz]] – IN arm-type binding domain – ''Yersinia pestis''<br />
**[[3ju0]] – HPI IN arm-type binding domain – ''Pectobacterium atrosepticum''<br />
**[[3ju0]] – HPI IN arm-type binding domain – ''Pectobacterium atrosepticum''<br />
 +
**[[8fti]] – IN (mutant) + RNA – ''Planctomycetota bacterium'' – Cryo EM<br />
**[[2kkp]] – IN SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
**[[2kkp]] – IN SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
**[[2kkv]] – IN fragment – ''Salmonella enterica'' – NMR<br />
**[[2kkv]] – IN fragment – ''Salmonella enterica'' – NMR<br />
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*Phage integrase
*Phage integrase
-
**[[3bvp]] – Integrase N-terminal – Lactococcus phage <br />
+
**[[3bvp]] – IN N-terminal – Lactococcus phage <br />
-
**[[1aih]] – HP1 integrase catalytic domain – bacteriophage<br />
+
**[[1aih]] – HP1 IN catalytic domain – bacteriophage<br />
**[[5dor]], [[5c6k]] – IN catalytic domain – Enterobacteria phage P2 <br />
**[[5dor]], [[5c6k]] – IN catalytic domain – Enterobacteria phage P2 <br />
**[[2wcc]], [[1kjk]] – λIN DBD+ DNA – Enterobacteria phage λ - NMR<br />
**[[2wcc]], [[1kjk]] – λIN DBD+ DNA – Enterobacteria phage λ - NMR<br />
Line 98: Line 136:
**[[1ae9]] – λIN catalytic core<br />
**[[1ae9]] – λIN catalytic core<br />
**[[5j0n]] – λIN + ATTP + ATTB + integration host factor + excisionase - Cryo EM<br />
**[[5j0n]] – λIN + ATTP + ATTB + integration host factor + excisionase - Cryo EM<br />
-
**[[5udo]] – IN coiled-coil domain – Listeria innocua phage <br />
+
**[[5uae]], [[5udo]] – IN coiled-coil domain – Listeria innocua phage <br />
*Yeast integrase
*Yeast integrase
Line 104: Line 142:
**[[1p4e]], 1m6x]] – FLP (mutant)+DNA <br />
**[[1p4e]], 1m6x]] – FLP (mutant)+DNA <br />
**[[1flo]] - FLP +DNA<br />
**[[1flo]] - FLP +DNA<br />
 +
**[[7z0h]], [[7z2z]], [[7z30]], [[7z31]] – IN + Pol III + DNA – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Retroviral Integrase

Updated on 19-October-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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