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Reverse transcriptase 3D structures

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* HIV-1 reverse transcriptase P66/P51
* HIV-1 reverse transcriptase P66/P51
-
**[[3dlk]], [[1hmv]] - P66/P51<br />
+
**[[1hmv]], [[3dlk]] - P66/P51<br />
-
**[[1mu2]], [[1jle]], [[1hpz]], [[1hqu]], [[1qe1]], [[1dlo]], [[2wom]], [[2won]], [[3tam]], [[4dg1]], [[4zhr]], [[4ifv]] - P66/P51 (mutant)<br />
+
**[[1mu2]], [[1jle]], [[1hpz]], [[1hqu]], [[1qe1]], [[1dlo]], [[2wom]], [[2won]], [[3tam]], [[4dg1]], [[4ifv]] - P66/P51 (mutant) <br />
-
**[[3qip]] - P66/P51 + NNRTI + RNase H inhibitor<br />
+
**[[3qip]] - P66/P51+ drug + RNase H inhibitor <br />
-
**[[3irx]], [[3is9]], [[3lak]], [[3lal]], [[3lam]], [[3lan]], [[3ffi]], [[3di6]], [[3dle]], [[3dlg]], [[2rki]], [[3c6t]], [[3c6u]], [[2rf2]], [[2vg5]], [[2vg6]], [[2vg7]], [[2opp]], [[1jlq]], [[1ep4]], [[1c0t]], [[1c0u]], [[1dtt]], [[1dtq]], [[1bqm]], [[1rt1]], [[1rt2]], [[1rev]], [[1rtj]], [[1vru]], [[1hnv]], [[1hni]], [[3t19]], [[5ki4]], [[5fdl]], [[5c24]], [[5c25]], [[4rw7]], [[5ter]], [[5k14]], [[2ynh]], [[2yni]], [[4ncg]], [[1c1b]], [[3lp0]], [[3lp1]], [[3lp2]], [[1vrt]], [[3hvt]], [[4i7f]], [[3m8p]], [[3mec]], [[3mee]], [[2zd1]], [[3qlh]], [[1ikw]], [[1fk9]], [[3dya]], [[3e01]], [[3drp]] - P66/P51+NNRTI<br />
+
**[[1c1b]], [[1jlq]], [[1ep4]], [[1c0t]], [[1c0u]], [[1dtt]], [[1dtq]], [[1bqm]], [[1fk9]], [[1ikw]], [[1rt1]], [[1rt2]], [[1rev]], [[1rt]]j, [[1vru]], [[1hnv]], [[1hni]], [[1vrt]], [[2rf2]], [[2rki]], [[2vg5]], [[2vg6]], [[2vg7]], [[2opp]], [[2yni]], [[2zd1]], [[3c6t]], [[3c6u]], [[3di6]], [[3dle]], [[3dlg]], [[3drp]], [[3dya]], [[3e01]], [[3ffi]], [[3hvt]], [[3irx]], [[3is9]], [[3lak]], [[3lal]], [[3lam]], [[3lan]], [[3lp0]], [[3lp1]], [[3lp2]], [[3m8p]], [[3mec]], [[3mee]], [[3qlh]], [[3t19]], [[4i7f]], [[4ncg]], [[5k14]], [[7so1]], [[7taz]], [[8fcc]], [[8fcd]], [[8fce]], [[8ffx]] - P66/P51+NNRTI<br />
-
**[[1s1t]], [[1s1v]], [[1s1w]], [[1s6p]], [[1s6q]], [[1s9e]], [[1s9g]], [[1suq]], [[1sv5]], [[3dm2]], [[3dmj]], [[3dok]], [[3dol]], [[2opq]], [[2opr]], [[2ops]], [[2ic3]], [[2hnz]], [[1jlg]], [[1bqn]], [[1uwb]], [[1tvr]], [[3qo9]], [[3t1a]], [[5c42]], [[5tw3]], [[4rw4]], [[4rw6]], [[4rw8]], [[2ynf]], [[2yng]], [[2ynf]], [[2yng]], [[4kko]], [[4lsl]], [[4lsn]], [[4mfb]], [[4o44]], [[4o4g]], [[1lw2]], [[1rt3]], [[6duh]], [[6dug]], [[6duf]], [[6cgf]], [[6c0r]], [[1jla]], [[6c0p]], [[6c0o]], [[6c0n]], [[6c0l]], [[6c0k]], [[6c0j]], [[5vqz]], [[5vqy]], [[5vqx]], [[5vqw]], [[5vqv]], [[5vqu]], [[5vqt]], [[5vqs]], [[5vqr]], [[5vqq]], [[6x47]], [[2ykm]], [[2ykn]], [[4h4m]], [[4h4o]], [[4rw4]], [[4rw6]], [[4rw7]], [[4rw8]], [[4rw9]], [[2iaj]], [[2hnd]], [[2hny]], [[1s1u]], [[1s1x]], [[1lw0]], [[1lwc]], [[1lwe]], [[1lwf]], [[1jlb]], [[1jlf]], [[1fkp]], [[3med]], [[3meg]], [[2ze2]], [[4g1q]], [[4icl]], [[4id5]], [[4idk]], [[4ify]], [[4ig0]], [[4ig3]], [[4kfb]], [[1jkh]], [[1ikv]], [[1fko]], [[3drr]], [[3drs]], [[6dtw]], [[6dtx]], [[6ul5]], [[2iaj]], [[6x49]], [[6x4a]], [[6x4b]], [[6x4c]], [[6x4d]], [[6x4e]], [[6x4f]] - P66/P51 (mutant)+NNRTI<br />
+
**[[1bqn]], [[1fko]], [[1fkp]], [[1ikv]], [[1jkh]], [[1jla]], [[1jlb]], [[1jlf]], [[1jlg]], [[1lw0]], [[1lw2, [[1lwc]], [[1lwe]], [[1lwf]], [[1rt3]], [[1s1t]], [[1s1u]], [[1s1v]], [[1s1w]], [[1s1x]], [[1s6p]], [[1s6q, [[1s9e]], [[1s9g]], [[1suq]], [[1sv5]], [[1tvr]], [[1uwb]], [[2iaj]], [[2hnd]], [[2hny]], [[2hnz]], [[2iaj]], [[2ic3]], [[2opq]], [[2opr]], [[2ops]], [[2ykm]], [[2ykn]], [[2ynf]], [[2yng]], [[2ynf]], [[2yng]], [[2ze2]], [[3dm2]], [[3dmj]], [[3dok]], [[3dol]], [[3drr]], [[3drs]], [[3med]], [[3meg]], [[3qo9]], [[3t1a]], [[4h4m]], [[4h4o]], [[4rw4]], [[4rw6]], [[4rw7]], [[4rw8]], [[4rw9]], [[4g1q]], [[4icl]], [[4id5]], [[4idk]], [[4ify]], [[4ig0]], [[4ig3]], [[4kfb]], [[4kko]], [[4lsl]], [[4lsn]], [[4mfb]], [[4o44]], [[4o4g]], [[6x47]], [[5vqz]], [[5vqy]], [[5vqx]], [[5vqw]], [[5vqv]], [[5vqu]], [[5vqt]], [[5vqs]], [[5vqr]], [[5vqq]], [[6cgf]], [[6c0r]], [[6c0p]], [[6c0o]], [[6c0n]], [[6c0l]], [[6c0k]], [[6c0j]], [[6dtw]], [[6dtx]], [[6duh]], [[6dug]], [[6duf]], [[6ul5]], [[6x49]], [[6x4a]], [[6x4b]], [[6x4c]], [[6x4d]], [[6x4e]], [[6x4f]], [[7so2]], [[7so3]], [[7so4]], [[7so6]] - P66/P51 (mutant)+NNRTI<br />
**[[4qag]] – Hiv1P66 + coumarin derivative <br />
**[[4qag]] – Hiv1P66 + coumarin derivative <br />
-
**[[1rti]] - P66/P51+ inhibitor<br />
+
**[[1rti]], [[7u5z]] - P66/P51+inhibitor<br />
-
**[[3ig1]] - P66/P51 + inhibitor beta-thujaplicinol<br />
+
**[[3ig1]] - P66/P51+ inhibitor beta-thujaplicinol<br />
-
**[[3i0r]], [[3i0s]], [[3m8q]], [[3isn]], [[3ith]], [[1c1c]], [[3nbp]], [[5vz6]] - P66/P51+ pyrimidine derivative<br />
+
**[[3i0r]], [[3i0s]], [[3m8q]], [[3isn]], [[3ith]], [[1c1c]], [[3nbp]], [[5vz6]], [[7krc]], [[7krd]], [[7kre]], [[7krf]], [[7snp]], [[7snz]] - P66/P51+ pyrimidine derivative<br />
-
**[[1ikx]], [[4ko0]], [[4we1]], [[6aoc]], [[5tuq]], [[6oe3]] - P66/P51 (mutant)+ pyrimidine derivative<br />
+
**[[1ikx]], [[4ko0]], [[6aoc]], [[5tuq]], [[6oe3]], [[7kwu]] - P66/P51 (mutant)+ pyrimidine derivative
**[[1tv6]] - P66/P51+ pyridine derivative<br />
**[[1tv6]] - P66/P51+ pyridine derivative<br />
 +
**[[1jlc]], [[1iky]], [[1eet]], [[8dxg]] - P66/P51(mutant)+ pyridine derivative<br />
**[[6eli]] - P66/P51+ pyridine derivative + rilpivirine + gag-pol polyprotein<br />
**[[6eli]] - P66/P51+ pyridine derivative + rilpivirine + gag-pol polyprotein<br />
-
**[[1jlc]], [[1iky]], [[1eet]] - P66/P51 (mutant) + pyridine derivative<br />
+
**[[8dx2]], [[8dx3]], [[8dx8]], [[8dxb]], [[8dxe]], [[8dxh]], [[8dxj]], [[8dxk]], [[8dxi]], [[8dxm]] - P66/P51 (mutant) + inhibitor + rilpivirine <br />
-
**[[5cym]], [[5cyq]] - P66/P51 (mutant) + pyrazole derivative<br />
+
**[[2b5j]], [[2ban]], [[2be2]], [[1rth]], [[4kv8]] - P66/P51+ pyridone derivative<br />
**[[2b5j]], [[2ban]], [[2be2]], [[1rth]], [[4kv8]] - P66/P51+ pyridone derivative<br />
**[[5j1e]], [[5hbm]] - P66/P51 (mutant) + pyridone derivative<br />
**[[5j1e]], [[5hbm]] - P66/P51 (mutant) + pyridone derivative<br />
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**[[6o9e]] - P66/P51 (mutant) + pyridone derivative + CMP<br />
**[[6o9e]] - P66/P51 (mutant) + pyridone derivative + CMP<br />
**[[1tkt]], [[1tkx]], [[1tkz]], [[1tl1]], [[1tl3]] - P66/P51+ quinoline derivative<br />
**[[1tkt]], [[1tkx]], [[1tkz]], [[1tl1]], [[1tl3]] - P66/P51+ quinoline derivative<br />
-
**[[5uv5]] - P66/P51 (mutant) + quinoline derivative <br />
+
**[[2b6a]] - P66/P51+ THR-50 <br />
-
**[[2b6a]] - P66/P51+ THR-50<br />
+
**[[2i5j]] - P66/P51 (mutant)+hydrazone derivative<br />
**[[2i5j]] - P66/P51 (mutant)+hydrazone derivative<br />
**[[1rt4]], [[1rt5]], [[1rt6]], [[1rt7]] - P66/P51+ carboxanilide derivative<br />
**[[1rt4]], [[1rt5]], [[1rt6]], [[1rt7]] - P66/P51+ carboxanilide derivative<br />
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* HIV-1 reverse transcriptase complex with DNA/RNA
* HIV-1 reverse transcriptase complex with DNA/RNA
-
**[[3kjv]], [[3kk3]], [[1r0a]], [[1n5y]], [[1n6q]], [[1hys]], [[5d3g]], [[5i3u]] - P66/P51+DNA<br />
+
**[[3kjv]], [[3kk3]], [[1r0a]], [[1n5y]], [[1n6q]], [[1hys]] - P66/P51+DNA <br />
-
**[[1j5o]], [[1rtd]], [[3klf]], [[3v4i]], [[3v6d]], [[6avt]], [[6avm]], [[6asw]], [[5j2q]], [[5j2p]], [[5j2m]], [[6or7]], [[6otz]], [[6oun]], [[6bhj]], [[6kdj]], [[6kdk]], [[6kdm]], [[6kdn]], [[6kdo]], [[6uir]], [[6uis]], [[6uit]], [[6ujx]], [[6ujy]], [[6ujz]], [[6uk0]] - P66/P51 (mutant)+DNA<br />
+
**[[1j5o]], [[1rtd]], [[3klf]], [[3v4i]], [[3v6d]], [[5d3g]], [[5j2q]], [[5j2p]], [[5j2m]], [[6avt]], [[6avm]], [[6asw]], [[6bhj]], [[6kdj]], [[6kdk]], [[6kdm]], [[6kdn]], [[6kdo]], [[6or7]], [[6otz]], [[6oun]], [[6uir]], [[6uis]], [[6uit]], [[6ujx]], [[6ujy]], [[6ujz]], [[6uk0]] - P66/P51 (mutant)+DNA<br />
-
**[[4r5p]], [[5j2n]], [[5txo]], [[5txp]] - P66/P51 (mutant) + nucleotide + DNA<br />
+
**[[4r5p]], [[7lri]], [[7lrm]], [[7lrx]], [[7lry]], [[7lsk]] - P66/P51 (mutant) + nucleotide + DNA<br />
-
**[[3v81]] - P66/P51 (mutant) + DNA + NNRTI<br />
+
**[[1hvu]] - P66/P51+RNA<br />
**[[1hvu]] - P66/P51+RNA<br />
-
**[[4b3o]], [[4b3p]], [[4b3q]], [[6bsj]], [[6bsi]], [[6bsh]], [[6bsg]] - P66/P51 + RNA + DNA<br />
+
**[[4b3o]], [[4b3p]], [[4b3q]], [[6bsj]], [[6bsi]], [[6bsh]], [[6bsg]] - P66/P51 + RNA + DNA<br />
**[[4pqu]] - P66/P51 (mutant) + dATP + RNA + DNA<br />
**[[4pqu]] - P66/P51 (mutant) + dATP + RNA + DNA<br />
**[[5i42]] - P66/P51 + dTTP + DNA<br />
**[[5i42]] - P66/P51 + dTTP + DNA<br />
**[[6anq]], [[6an8]], [[6an2]], [[6amo]] - P66/P51 (mutant) + dTTP + DNA<br />
**[[6anq]], [[6an8]], [[6an2]], [[6amo]] - P66/P51 (mutant) + dTTP + DNA<br />
-
**[[6p1i]], [[6p1x]], [[6p2g]] - P66/P51 (mutant) + dCTP + DNA<br />
+
**[[6wph]] - P66/P51 (mutant) + dGMP + DNA<br />
 +
**[[6wpj]] - P66/P51 (mutant) + dGMP + dTTP + DNA<br />
 +
**[[6wpf]] - P66/P51 (mutant) + dGMP + dTTP + DNA + NNRTI<br />
 +
**[[6p1i]], [[6p1x]], [[6p2g]], [[7dbn]] - P66/P51 (mutant) + dCTP + DNA<br />
 +
**[[7dbm]] - P66/P51 (mutant) + dGTP + DNA<br />
**[[6ik9]] - P66/P51 (mutant) + dCMP + GTP + DNA<br />
**[[6ik9]] - P66/P51 (mutant) + dCMP + GTP + DNA<br />
**[[5txn]], [[5txm]], [[5txl]] - P66/P51 (mutant) + dATP + DNA<br />
**[[5txn]], [[5txm]], [[5txl]] - P66/P51 (mutant) + dATP + DNA<br />
**[[6b19]] - P66/P51 (mutant) + tRNA + RNA<br />
**[[6b19]] - P66/P51 (mutant) + tRNA + RNA<br />
**[[6waz]], [[6wb0]], [[6wb1]], [[6wb2]] - P66/P51 (mutant) + tRNA + RNA – Cryo EM<br />
**[[6waz]], [[6wb0]], [[6wb1]], [[6wb2]] - P66/P51 (mutant) + tRNA + RNA – Cryo EM<br />
 +
**[[7kjv]], [[7ljw]], [[7kjx]] - P66/P51 (mutant) + drug + RNA – Cryo EM<br />
 +
**[[7z24]], [[7z2d]], [[7z2g]] - P66/P51 + drug + DNA – Cryo EM<br />
 +
**[[7ahx]], [[7aid]], [[7aif]], [[7aig]], [[7aii]], [[7aij]] - P66/P51 (mutant) + drug + DNA – Cryo EM<br />
**[[4puo]], [[4pwd]], [[4q0b]] - P66/P51 (mutant) + NNRTI + RNA + DNA<br />
**[[4puo]], [[4pwd]], [[4q0b]] - P66/P51 (mutant) + NNRTI + RNA + DNA<br />
-
**[[1t03]], [[1t05]] - P66/P51+DNA+Fab+NNRTI<br />
+
**[[1t03]], ]]1t05]] - P66/P51+DNA+ antibody +NNRTI<br />
-
**[[3jsm]] - P66/P51 (mutant)+DNA+NNRTI<br />
+
**[[3kk2]], [[7ot6]], [[7ota]], [[7otk]], [[7otn]], [[7otx]], [[7otz]], [[7out]], [[7oxu]], [[7oz2]], [[7oz5]] - P66/P51+DNA+NNRTI<br />
-
**[[2hmi]] - P66/P51 (mutant)+DNA+Fab<br />
+
**[[7kjw]] - P66/P51 (mutant) +DNA+ drug – Cryo EM<br />
-
**[[3kk1]] - P66/P51 (mutant)+DNA + inhibitor<br />
+
**[[3jsm]], [[3jyt]], [[3kk1]], [[3v81]], [[7lpw]], [[7lpx]], [[7lqu]], [[7ozw]], [[7p15]] - P66/P51 (mutant)+DNA+NNRTI<br />
-
**[[3kk2]] - P66/P51+DNA+NNRTI<br />
+
**[[2hmi]], [[6vug]] - P66/P51 (mutant)+DNA+ antibody<br />
-
**[[3jyt]] - P66/P51 (mutant)+DNA+NNRTI<br />
+
-
**[[4r5p]], [[5hlf]], [[5hp1]], [[5hro]] - P66/P51 + DNA + phosphonate inhibitor<br />
+
*HIV-1 AZT-resistant reverse transcriptase P66/P51
*HIV-1 AZT-resistant reverse transcriptase P66/P51
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**[[3kli]] - P66/P51 (mutant)<br />
**[[3kli]] - P66/P51 (mutant)<br />
**[[3kle]], [[3klg]], [[3klh]] – P66/P51 (mutant) + DNA
**[[3kle]], [[3klg]], [[3klh]] – P66/P51 (mutant) + DNA
 +
 +
*HIV-1 NNRTI-resistant RT P66/P51
 +
 +
**[[7z29]] - P66/P51 (mutant) + DNA – Cryo EM<br />
 +
**[[7z2e]], [[7z2h]] - P66/P51 (mutant) + DNA + drug – Cryo EM<br />
*HIV-1 reverse transcriptase P66
*HIV-1 reverse transcriptase P66
-
''Italic text''
+
 
-
**[[2jle]] – P66+NNRTI<br />
+
**[[2jle]], [[7slr]], [[7sls]] – P66+NNRTI<br />
**[[1har]] - P66 N-terminal<br />
**[[1har]] - P66 N-terminal<br />
**[[5t82]] - P66 thumb domain - NMR<br />
**[[5t82]] - P66 thumb domain - NMR<br />
 +
**[[7oxq]] – P66 + Gag-Pol polyprotein + DNA + pyrazole derivative<br />
-
*Hiv-1 P15
+
*HIV-1 P15 RNase H domain 167-240
**[[1rdh]], [[1hrh]], [[5dzm]] – P15<br />
**[[1rdh]], [[1hrh]], [[5dzm]] – P15<br />
-
**[[3lp3]] – P15+inhibitor MK3<br />
+
**[[3lp3]], [[7xis]], [[7xit]], [[7xiu]], [[7xj4]], [[7xj5]], [[7xj7]] – P15+inhibitor MK3<br />
**[[3k2p]] – P15+inhibitor beta-thujaplicinol<br />
**[[3k2p]] – P15+inhibitor beta-thujaplicinol<br />
**[[3hyf]] – P15+pyrimidine derivative<br />
**[[3hyf]] – P15+pyrimidine derivative<br />
**[[1o1w]] – P15+Mg - NMR<br />
**[[1o1w]] – P15+Mg - NMR<br />
 +
**[[8jyh]], [[8jyi]], [[8jyj]] – P15+ laccaic acid<br />
*HIV-2 reverse transcriptase
*HIV-2 reverse transcriptase
Line 90: Line 100:
**[[4xo0]], [[4xpc]], [[4xpe]], [[5vbs]], [[4m94]], [[4m95]], [[6b1q]], [[6b1r]], [[6b1s]] – MmlvRT catalytic fragment residues 683-937 +DNA<br />
**[[4xo0]], [[4xpc]], [[4xpe]], [[5vbs]], [[4m94]], [[4m95]], [[6b1q]], [[6b1r]], [[6b1s]] – MmlvRT catalytic fragment residues 683-937 +DNA<br />
**[[4mh8]] – MmlvRT P80 residues 683-1330 (mutant)<br />
**[[4mh8]] – MmlvRT P80 residues 683-1330 (mutant)<br />
-
**[[1i6j]], [[1d0e]], [[1d1u]], [[1qaj]], [[1qai]], [[6mih]], [[6mik]] – MmlvRT N-terminal+DNA<br />
+
**[[1i6j]], [[1d0e]], [[1d1u]], [[1qaj]], [[1qai]], [[6mih]], [[6mik]], [[7uyn]], [[7uyo]], [[7uyp]], [[8cs0]], [[8dw1]] – MmlvRT N-terminal+DNA<br />
*Xenotropic mulv-related virus reverse transcriptase
*Xenotropic mulv-related virus reverse transcriptase

Current revision

3D Structures of Reverse transcriptase

Updated on 19-October-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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