This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8k4n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8k4n is ON HOLD Authors: Wong, T.S., Zeng, Z.C., Xiong, T.T., Gan, S.Y., He, G.D., Du, Y. Description: Structure of GPR34-Gi complex [[Category: Un...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of GPR34-Gi complex== | |
| - | + | <StructureSection load='8k4n' size='340' side='right'caption='[[8k4n]], [[Resolution|resolution]] 2.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8k4n]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K4N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.83Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VF0:(2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic+acid'>VF0</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k4n OCA], [https://pdbe.org/8k4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k4n RCSB], [https://www.ebi.ac.uk/pdbsum/8k4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k4n ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: He | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Du Y]] | ||
| + | [[Category: Gan SY]] | ||
| + | [[Category: He GD]] | ||
| + | [[Category: Wong TS]] | ||
| + | [[Category: Xiong TT]] | ||
| + | [[Category: Zeng ZC]] | ||
Current revision
Structure of GPR34-Gi complex
| |||||||||||
Categories: Homo sapiens | Large Structures | Synthetic construct | Du Y | Gan SY | He GD | Wong TS | Xiong TT | Zeng ZC
