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1is3

From Proteopedia

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LACTOSE AND MES-LIGANDED CONGERIN II

Structural highlights

1is3 is a 1 chain structure with sequence from Conger myriaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.45Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEG2_CONMY This protein binds beta-galactoside. Its physiological function is not yet known.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.

Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication.,Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K. Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication. J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:12206768

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1is3"

@@ Line 3: / Line 3: @@
 <StructureSection load='1is3' size='340' side='right'caption='[[1is3]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1is3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anguilla_myriaster Anguilla myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IS3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1is3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IS3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c1l|1c1l]], [[1is4|1is4]], [[1is5|1is5]], [[1is6|1is6]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1is3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is3 OCA], [http://pdbe.org/1is3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1is3 RCSB], [http://www.ebi.ac.uk/pdbsum/1is3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1is3 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1is3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is3 OCA], [https://pdbe.org/1is3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1is3 RCSB], [https://www.ebi.ac.uk/pdbsum/1is3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1is3 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/LEG2_CONMY LEG2_CONMY]] This protein binds beta-galactoside. Its physiological function is not yet known.
+[https://www.uniprot.org/uniprot/LEG2_CONMY LEG2_CONMY] This protein binds beta-galactoside. Its physiological function is not yet known.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Anguilla myriaster]]
+[[Category: Conger myriaster]]
 [[Category: Large Structures]]
-[[Category: Ishii, C]]
+[[Category: Ishii C]]
-[[Category: Kamiya, H]]
+[[Category: Kamiya H]]
-[[Category: Matsui, Y]]
+[[Category: Matsui Y]]
-[[Category: Muramoto, K]]
+[[Category: Muramoto K]]
-[[Category: Ogawa, T]]
+[[Category: Ogawa T]]
-[[Category: Shionyu-Mitsuyama, C]]
+[[Category: Shionyu-Mitsuyama C]]
-[[Category: Shirai, T]]
+[[Category: Shirai T]]
-[[Category: Yamane, T]]
+[[Category: Yamane T]]
-[[Category: Complex with lactose and me]]
-[[Category: Sugar binding protein]]

1is3

From Proteopedia

Current revision

LACTOSE AND MES-LIGANDED CONGERIN II

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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