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1scq

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==K236L mutant of hydroxynitrile lyase from Hevea brasiliensis in complex with acetonecyanohydrin==
==K236L mutant of hydroxynitrile lyase from Hevea brasiliensis in complex with acetonecyanohydrin==
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<StructureSection load='1scq' size='340' side='right' caption='[[1scq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='1scq' size='340' side='right'caption='[[1scq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1scq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hevbr Hevbr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SCQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1scq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hevea_brasiliensis Hevea brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SCQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CNH:2-HYDROXY-2-METHYLPROPANENITRILE'>CNH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qj4|1qj4]], [[1yas|1yas]], [[2yas|2yas]], [[3yas|3yas]], [[4yas|4yas]], [[5yas|5yas]], [[6yas|6yas]], [[7yas|7yas]], [[1sc9|1sc9]], [[1sci|1sci]], [[1sck|1sck]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNH:2-HYDROXY-2-METHYLPROPANENITRILE'>CNH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3981 HEVBR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1scq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1scq OCA], [https://pdbe.org/1scq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1scq RCSB], [https://www.ebi.ac.uk/pdbsum/1scq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1scq ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.46 and 4.1.2.47 4.1.2.46 and 4.1.2.47] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1scq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1scq OCA], [http://pdbe.org/1scq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1scq RCSB], [http://www.ebi.ac.uk/pdbsum/1scq PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HNL_HEVBR HNL_HEVBR]] Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin.
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[https://www.uniprot.org/uniprot/HNL_HEVBR HNL_HEVBR] Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1scq_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sc/1scq_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hevbr]]
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[[Category: Hevea brasiliensis]]
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[[Category: Lyase]]
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[[Category: Large Structures]]
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[[Category: Gartler, G]]
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[[Category: Gartler G]]
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[[Category: Gruber, K]]
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[[Category: Gruber K]]
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[[Category: Krammer, B]]
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[[Category: Krammer B]]
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[[Category: Kratky, C]]
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[[Category: Kratky C]]
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[[Category: Schwab, H]]
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[[Category: Schwab H]]
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[[Category: Alpha-beta hydrolase fold]]
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[[Category: Catalytic triad]]
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[[Category: Substrate complex]]
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Current revision

K236L mutant of hydroxynitrile lyase from Hevea brasiliensis in complex with acetonecyanohydrin

PDB ID 1scq

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