1v5x

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{{Seed}}
 
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[[Image:1v5x.png|left|200px]]
 
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==Crystal structure of Phosphoribosyl anthranilate isomerase from Thermus Thermophilus==
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The line below this paragraph, containing "STRUCTURE_1v5x", creates the "Structure Box" on the page.
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<StructureSection load='1v5x' size='340' side='right'caption='[[1v5x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1v5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5x OCA], [https://pdbe.org/1v5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5x RCSB], [https://www.ebi.ac.uk/pdbsum/1v5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5x ProSAT], [https://www.topsan.org/Proteins/RSGI/1v5x TOPSAN]</span></td></tr>
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{{STRUCTURE_1v5x| PDB=1v5x | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83825_THETH P83825_THETH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v5x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v5x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of phosphoribosyl anthranilate isomerase (PRAI) from Thermus thermophilus HB8 (TtPRAI) was solved at 2.0 A resolution. The overall structure of TtPRAI with a dimeric structure was quite similar to that of PRAI from Thermotoga maritima (TmPRAI). In order to elucidate the stabilization mechanism of TtPRAI, its physicochemical properties were examined using DSC, CD, and analytical centrifugation at various pHs in relation to the association-dissociation of the subunits. Based on the experimental results for TtPRAI and the structural information on TtPRAI and TmPRAI, we found that: (i) the denaturation of TtPRAI at acidic pH is correlated with the dissociation of its dimeric form; (ii) the hydrophobic interaction of TtPRAI in the monomer structure is slightly greater than that of TmPRAI, but dimer interface of the TmPRAI is remarkably greater; (iii) the contributions of hydrogen bonds and ion bonds to the stability are similar to each other; and (iv) destabilization due to the presence of cavities in TtPRAI is greater than that of TmPRAI in both the monomer and dimer structures.
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===Crystal structure of Phosphoribosyl anthranilate isomerase from Thermus Thermophilus===
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Stabilization due to dimer formation of phosphoribosyl anthranilate isomerase from Thermus thermophilus HB8: X-ray Analysis and DSC experiments.,Taka J, Ogasahara K, Jeyakanthan J, Kunishima N, Kuroishi C, Sugahara M, Yokoyama S, Yutani K J Biochem. 2005 May;137(5):569-78. PMID:15944409<ref>PMID:15944409</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15944409}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1v5x" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15944409 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15944409}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1V5X is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5X OCA].
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==Reference==
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Stabilization due to dimer formation of phosphoribosyl anthranilate isomerase from Thermus thermophilus HB8: X-ray Analysis and DSC experiments., Taka J, Ogasahara K, Jeyakanthan J, Kunishima N, Kuroishi C, Sugahara M, Yokoyama S, Yutani K, J Biochem. 2005 May;137(5):569-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15944409 15944409]
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[[Category: Phosphoribosylanthranilate isomerase]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Kunishima, N.]]
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[[Category: Kunishima N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Taka J]]
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[[Category: Taka, J.]]
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[[Category: Yutani K]]
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[[Category: Yutani, K.]]
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[[Category: Alpha-beta barrel]]
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[[Category: Isomerase]]
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[[Category: Phosphoribosyl anthranilate isomerase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Trpf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:58:54 2008''
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Current revision

Crystal structure of Phosphoribosyl anthranilate isomerase from Thermus Thermophilus

PDB ID 1v5x

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