This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1vgn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:55, 25 October 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1vgn.gif|left|200px]]
 
-
{{Structure
+
==Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)==
-
|PDB= 1vgn |SIZE=350|CAPTION= <scene name='initialview01'>1vgn</scene>, resolution 2.63&Aring;
+
<StructureSection load='1vgn' size='340' side='right'caption='[[1vgn]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
+
<table><tr><td colspan='2'>[[1vgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGN FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgn OCA], [https://pdbe.org/1vgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgn RCSB], [https://www.ebi.ac.uk/pdbsum/1vgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgn ConSurf].
 +
<div style="clear:both"></div>
-
'''Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)'''
+
==See Also==
-
 
+
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1VGN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester., Kurosaki H, Yamaguchi Y, Higashi T, Soga K, Matsueda S, Yumoto H, Misumi S, Yamagata Y, Arakawa Y, Goto M, Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3861-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15892033 15892033]
+
-
[[Category: Beta-lactamase]]
+
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
-
[[Category: Single protein]]
+
[[Category: Arakawa Y]]
-
[[Category: Arakawa, Y.]]
+
[[Category: Goto M]]
-
[[Category: Goto, M.]]
+
[[Category: Higashi T]]
-
[[Category: Higashi, T.]]
+
[[Category: Kurosaki H]]
-
[[Category: Kurosaki, H.]]
+
[[Category: Matsueda S]]
-
[[Category: Matsueda, S.]]
+
[[Category: Misumi S]]
-
[[Category: Misumi, S.]]
+
[[Category: Soga K]]
-
[[Category: Soga, K.]]
+
[[Category: Yamagata Y]]
-
[[Category: Yamagata, Y.]]
+
[[Category: Yamaguchi Y]]
-
[[Category: Yamaguchi, Y.]]
+
-
[[Category: ACY]]
+
-
[[Category: OPS]]
+
-
[[Category: ZN]]
+
-
[[Category: irreversible inhibitor]]
+
-
[[Category: metallo-beta-lactamase]]
+
-
[[Category: zinc]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:45:18 2008''
+

Current revision

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

PDB ID 1vgn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vgn"
Personal tools