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1vgn

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{{Seed}}
 
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[[Image:1vgn.png|left|200px]]
 
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<!--
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==Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)==
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The line below this paragraph, containing "STRUCTURE_1vgn", creates the "Structure Box" on the page.
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<StructureSection load='1vgn' size='340' side='right'caption='[[1vgn]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=OPS:3-OXO-3-[(3-OXOPROPYL)SULFANYL]PROPANE-1-THIOLATE'>OPS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1vgn| PDB=1vgn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgn OCA], [https://pdbe.org/1vgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgn RCSB], [https://www.ebi.ac.uk/pdbsum/1vgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgn ConSurf].
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<div style="clear:both"></div>
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===Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1VGN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGN OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:15892033</ref><references group="xtra"/>
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[[Category: Beta-lactamase]]
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[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
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[[Category: Arakawa, Y.]]
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[[Category: Arakawa Y]]
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[[Category: Goto, M.]]
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[[Category: Goto M]]
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[[Category: Higashi, T.]]
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[[Category: Higashi T]]
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[[Category: Kurosaki, H.]]
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[[Category: Kurosaki H]]
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[[Category: Matsueda, S.]]
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[[Category: Matsueda S]]
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[[Category: Misumi, S.]]
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[[Category: Misumi S]]
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[[Category: Soga, K.]]
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[[Category: Soga K]]
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[[Category: Yamagata, Y.]]
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[[Category: Yamagata Y]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Yamaguchi Y]]
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[[Category: Irreversible inhibitor]]
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[[Category: Metallo-beta-lactamase]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:45:22 2009''
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Current revision

Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1)

PDB ID 1vgn

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