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1xh2

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==Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride and acarbose==
==Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride and acarbose==
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<StructureSection load='1xh2' size='340' side='right' caption='[[1xh2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1xh2' size='340' side='right'caption='[[1xh2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xh2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XH2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XH2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARE:ACARBOSE+DERIVED+PENTASACCHARIDE'>ARE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARE:ACARBOSE+DERIVED+PENTASACCHARIDE'>ARE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xgz|1xgz]], [[1xh0|1xh0]], [[1xh1|1xh1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xh2 OCA], [https://pdbe.org/1xh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1xh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xh2 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xh2 OCA], [http://pdbe.org/1xh2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xh2 RCSB], [http://www.ebi.ac.uk/pdbsum/1xh2 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xh2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/1xh2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Amylase|Amylase]]
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*[[Amylase 3D structures|Amylase 3D structures]]
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*[[User:Gabriel Pons/Sandbox 2|User:Gabriel Pons/Sandbox 2]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alpha-amylase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Begum, A]]
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[[Category: Begum A]]
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[[Category: Brayer, G D]]
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[[Category: Brayer GD]]
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[[Category: Kuo, H H]]
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[[Category: Kuo HH]]
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[[Category: Maurus, R]]
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[[Category: Maurus R]]
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[[Category: Numao, S]]
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[[Category: Numao S]]
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[[Category: Overall, C M]]
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[[Category: Overall CM]]
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[[Category: Racaza, A]]
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[[Category: Racaza A]]
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[[Category: Withers, S G]]
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[[Category: Withers SG]]
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[[Category: Chloride amylase enzyme acarbose]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

Structure of the N298S variant of human pancreatic alpha-amylase complexed with chloride and acarbose

PDB ID 1xh2

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