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1xwv
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1xwv.png|left|200px]] | ||
| - | < | + | ==Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity== |
| - | + | <StructureSection load='1xwv' size='340' side='right'caption='[[1xwv]], [[Resolution|resolution]] 1.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1xwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |
| - | - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwv OCA], [https://pdbe.org/1xwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwv RCSB], [https://www.ebi.ac.uk/pdbsum/1xwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwv ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALL2_DERFA ALL2_DERFA] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwv_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwv ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes. | ||
| - | + | Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.,Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415<ref>PMID:15710415</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1xwv" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | |
| - | + | ||
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Dermatophagoides farinae]] | [[Category: Dermatophagoides farinae]] | ||
| - | [[Category: Bolwig | + | [[Category: Large Structures]] |
| - | [[Category: Gajhede | + | [[Category: Bolwig C]] |
| - | [[Category: Johannessen | + | [[Category: Gajhede M]] |
| - | [[Category: Kastrup | + | [[Category: Johannessen BR]] |
| - | [[Category: Kristensen | + | [[Category: Kastrup JS]] |
| - | [[Category: Larsen | + | [[Category: Kristensen O]] |
| - | [[Category: Lund | + | [[Category: Larsen JN]] |
| - | [[Category: Skov | + | [[Category: Lund K]] |
| - | [[Category: Spangfort | + | [[Category: Skov LK]] |
| - | + | [[Category: Spangfort M]] | |
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Current revision
Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity
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