This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xxu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:09, 25 October 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin==
==Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin==
-
<StructureSection load='1xxu' size='340' side='right' caption='[[1xxu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+
<StructureSection load='1xxu' size='340' side='right'caption='[[1xxu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXU FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1xxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXU FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xvw|1xvw]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2238c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxu OCA], [https://pdbe.org/1xxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxu RCSB], [https://www.ebi.ac.uk/pdbsum/1xxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxu ProSAT], [https://www.topsan.org/Proteins/TBSGC/1xxu TOPSAN]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xxu RCSB], [http://www.ebi.ac.uk/pdbsum/1xxu PDBsum], [http://www.topsan.org/Proteins/TBSGC/1xxu TOPSAN]</span></td></tr>
+
== Function ==
-
<table>
+
[https://www.uniprot.org/uniprot/AHPE_MYCTU AHPE_MYCTU] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection.<ref>PMID:19737009</ref> <ref>PMID:24379404</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxu_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxu_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 26: Line 27:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 1xxu" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Peroxidase]]
+
[[Category: Baker EN]]
-
[[Category: Baker, E N.]]
+
[[Category: Hung LW]]
-
[[Category: Hung, L W.]]
+
[[Category: Kim CY]]
-
[[Category: Kim, C Y.]]
+
[[Category: Kim MY]]
-
[[Category: Kim, M Y.]]
+
[[Category: Lekin T]]
-
[[Category: Lekin, T.]]
+
[[Category: Li S]]
-
[[Category: Li, S.]]
+
[[Category: Lott JS]]
-
[[Category: Lott, J S.]]
+
[[Category: Peterson NA]]
-
[[Category: Peterson, N A.]]
+
[[Category: Segelke BW]]
-
[[Category: Segelke, B W.]]
+
[[Category: Yu M]]
-
[[Category: TBSGC, TB Structural Genomics Consortium.]]
+
-
[[Category: Yu, M.]]
+
-
[[Category: 1-cys peroxiredoxin]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Tb structural genomics consortium]]
+
-
[[Category: Tbsgc]]
+
-
[[Category: Thioredoxin fold]]
+

Current revision

Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin

PDB ID 1xxu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xxu"
Personal tools