1ycj
From Proteopedia
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(New page: 200px<br /><applet load="1ycj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ycj, resolution 1.95Å" /> '''Crystal structure of...) |
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| - | [[Image:1ycj.gif|left|200px]]<br /><applet load="1ycj" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1ycj, resolution 1.95Å" /> | ||
| - | '''Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate'''<br /> | ||
| - | == | + | ==Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate== |
| - | The X-ray structure of the ligand-binding core of the kainate receptor | + | <StructureSection load='1ycj' size='340' side='right'caption='[[1ycj]], [[Resolution|resolution]] 1.95Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1ycj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycj OCA], [https://pdbe.org/1ycj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycj RCSB], [https://www.ebi.ac.uk/pdbsum/1ycj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J. | ||
| - | + | Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate.,Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405<ref>PMID:15710405</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1ycj" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Egebjerg J]] | ||
| + | [[Category: Gajhede M]] | ||
| + | [[Category: Kastrup JS]] | ||
| + | [[Category: Naur P]] | ||
| + | [[Category: Skov LK]] | ||
| + | [[Category: Vestergaard B]] | ||
Current revision
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
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