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1ycj

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(New page: 200px<br /><applet load="1ycj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ycj, resolution 1.95&Aring;" /> '''Crystal structure of...)
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[[Image:1ycj.gif|left|200px]]<br /><applet load="1ycj" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ycj, resolution 1.95&Aring;" />
 
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'''Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate'''<br />
 
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==Overview==
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==Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate==
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The X-ray structure of the ligand-binding core of the kainate receptor, GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A, resolution. The overall GluR5-S1S2 structure comprises two domains and is, similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as, in GluR2-S1S2J. Distinct features are observed for Ser741, which, stabilizes a highly coordinated network of water molecules and forms an, interdomain bridge. The GluR5 complex exhibits a high degree of domain, closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2, forms a novel dimer interface with a different arrangement of the two, protomers compared to GluR2-S1S2J.
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<StructureSection load='1ycj' size='340' side='right'caption='[[1ycj]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ycj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycj OCA], [https://pdbe.org/1ycj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycj RCSB], [https://www.ebi.ac.uk/pdbsum/1ycj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J.
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==About this Structure==
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Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate.,Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405<ref>PMID:15710405</ref>
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1YCJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with SO4 and GLU as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YCJ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate., Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS, FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15710405 15710405]
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</div>
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[[Category: Rattus norvegicus]]
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<div class="pdbe-citations 1ycj" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Egebjerg, J.]]
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[[Category: Gajhede, M.]]
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[[Category: Kastrup, J.S.]]
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[[Category: Naur, P.]]
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[[Category: Skov, L.K.]]
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[[Category: Vestergaard, B.]]
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[[Category: GLU]]
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[[Category: SO4]]
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[[Category: glur5 ligand-binding core]]
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[[Category: ionotropic glutamate receptor]]
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[[Category: kainate receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:41:04 2007''
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Egebjerg J]]
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[[Category: Gajhede M]]
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[[Category: Kastrup JS]]
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[[Category: Naur P]]
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[[Category: Skov LK]]
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[[Category: Vestergaard B]]

Current revision

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

PDB ID 1ycj

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