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1yv4

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==X-ray structure of M23L onconase at 100K==
==X-ray structure of M23L onconase at 100K==
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<StructureSection load='1yv4' size='340' side='right' caption='[[1yv4]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
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<StructureSection load='1yv4' size='340' side='right'caption='[[1yv4]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Litpi Litpi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YV4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YV4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yv6|1yv6]], [[1yv7|1yv7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yv4 OCA], [https://pdbe.org/1yv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yv4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yv4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yv4 OCA], [http://pdbe.org/1yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yv4 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RNP30_RANPI RNP30_RANPI]] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Litpi]]
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[[Category: Large Structures]]
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[[Category: Carannante, A]]
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[[Category: Lithobates pipiens]]
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[[Category: Donato, A Di]]
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[[Category: Carannante A]]
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[[Category: Fiore, A Di]]
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[[Category: Di Donato A]]
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[[Category: Mazzarella, L]]
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[[Category: Di Fiore A]]
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[[Category: Merlino, A]]
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[[Category: Mazzarella L]]
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[[Category: Notomista, E]]
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[[Category: Merlino A]]
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[[Category: Sica, F]]
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[[Category: Notomista E]]
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[[Category: Antitumor action]]
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[[Category: Sica F]]
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[[Category: Dynamic]]
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[[Category: Hydrolase]]
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[[Category: Onconase thermal stability]]
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[[Category: Ribonuclease]]
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[[Category: Small conformational change]]
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Current revision

X-ray structure of M23L onconase at 100K

PDB ID 1yv4

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